アスコルビン酸カルシウムを配合した製剤を経口投与したときのビタミンCの血漿濃度と尿中排泄量

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We have examined the plasma and urinary levels of vitamin C after oral administration of calcium ascorbate preparation in six healthy males(20〜27 years). They were given a preparation A or B in a two-period crossover trial. A contains 363 mg of calcium ascorbate and 700 mg of ascorbic acid, and B contains 1000 mg of ascorbic acid. The mean plasma concentration of vitamin C at 1 and 2 h was lower (p < 0.05), but was higher (p < 0.05) at 6 and 9 h in A than that in B. Truax was 3 h for both preparations. The mean Cmax (mg/100 ml, above the initial value) was 1.11 for A and 1.09 for B. The mean AUC_<0-24>(mg・h/100 ml)was 10.57 for A and 10.13 for B. The MRT_<0-24> (h) for A was 8.20 compared to 7.82 for B (p<0.05>). The MRT_<0-∞>(h) was 15.21 and 14.68 for A and B, respectively. The mean amount of vitamin C (mg, above the initial value) excreted in urine during the 0-3 h was 38 for A and 53 for B (p<0.05). During 3-6 h it was 133 and 122 (p<0.05) for A and B, respectively. The percentage of the dose excreted during the 0-24 h was essentially the same: 27.0 % for A and 26.7 % for B. The mean urinary excretion of oxalic acid (mg/24 h) following vitamin C administration was 33.7 for A and 34.8 for B, but the increase of oxalic acid was minor. In conclusion, we found that although minor differences were observed in absoption rate and residence time between A and B, calcium ascorbate and ascorbic acid show similar pharmacokinetics after oral administration.
日本ビタミン学会の論文
1998-10-25

アスコルビン酸カルシウムを配合した製剤を経口投与したときのビタミンCの血漿濃度と尿中排泄量

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