2価鉄-アスコルビン酸錯体のT5ファージに対する不活化作用

概要

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The inactivating effect of iron(II)-ascorbate complex ([Fe(II)-ascorbate]) on various phages was previously reported. This paper describes the inactivating effect of [Fe(II)-ascorbate] on phage T5, a phage less sensitive to [Fe(II)-ascorbate]. The inactivation of phage by [Fe(II)-ascorbate] was irreversible. The bubbling of nitrogen gas through the reaction mixture and the addition to the reaction mixture of reducing agents, Fe^<3+>, chelating agents, or radical scavengers inhibited the inactivation by [Fe(II)-ascorbate]. Addition of Fe^<2+> enhanced the inactivation, while H_2O_2, Cu^+, Cu^<2+>, Mg^<2+>, catalase and superoxide dismutase had little or no effect on the inactivation. These findings suggest the possible involvement of active oxygen in the phage in activation by [Fe(II)-ascorbate].
日本ビタミン学会の論文
1992-06-25