Mushroom Tyrosinase Inhibitory Activity of Esculetin Isolated from Seeds of Euphorbia lathyris L.(Organic Chemistry)
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概要
- 論文の詳細を見る
A tyrosinase inhibitor was isolated from the seeds of Euphorbia lathyris L. by bioassay-guided fractionation and purification, using silica gel column chromatography. It was identified as esculetin by comparing its physical properties and spectral data with those of an authentic sample. The IC_<50> value of esculetin in the mushroom tyrosinase activity test was 43 μM. The kinetic study indicates that esculetin exhibited competitive inhibition against the oxidation of 3- (3, 4-dihydroxyphenyl) -alanine by mushroom tyrosinase. The structureactivity relationships among five esculetin analogs suggest that hydroxyl groups at the C6 and C7 positions of the coumarin skeleton played an important role in the expression of tyrosinase inhibitory activity.
- 社団法人日本農芸化学会の論文
- 2003-03-23
著者
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Murata Y
Graduate School Of Natural Science And Technology Okayama University
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Miura Yoshie
川崎医科大学 衛生学
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Miura Yoshie
Dep. Of Biofunctional Chemistry Graduate School Of Natural Sci. And Technol. Okayama Univ.
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ANDO Hideya
R&D Center, SUNSTAR Inc.
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TAKAHATA Kyoya
Faculty of Agriculture, Okayama University
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TADA Mikiro
Graduate School of National Science and Technology, Okayama University
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MURATA Yoshiyuki
Faculty of Agriculture, Okayama University
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SHIMOISHI Yasuaki
Faculty of Agriculture, Okayama University
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MASAMOTO Yukimitsu
Graduate School of Natural Science and Technology, Okayama University
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Shimoishi Yasuaki
Div. Of Bioscience Graduate School Of Natural Sci. And Technol. Okayama Univ.
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Masamoto Yukimitsu
Graduate School Of Natural Science And Technology Okayama University
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Takahata K
Faculty Of Agriculture Okayama University
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Ando Hideya
R&d Center Sunstar Inc.
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Tada M
Department Of Biological Resources Chemistry Faculty Of Agriculture Okayama University
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Takahata Kyoya
Faculty Of Agriculture Okayama University
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Murata Yoshiyuki
Graduate School Of Natural Science And Technology Okayama University
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Tada Mikiro
Fac. Of Agriculture Okayama Univ.
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Murata Yoshiyuki
Okayama Univ. Okayama Jpn
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Shimoishi Yasuaki
Graduate School Of Natural Science And Technology Okayama University
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