Effect of Dimethyl Sulfides on the Induction of Apoptosis in Human Leukemia Jurkat Cells and HL-60 Cells
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概要
- 論文の詳細を見る
Organosulfur compounds have been established to possess anticancer effects. To provide a better understanding of the biological function of dimethyl sulfides, dimethyl monosulfide (Me2S), dimethyl disulfide (Me2S2), dimethyl trisulfide (Me2S3) and dimethyl tetrasulfide (Me2S4) were used as experimental materials to investigate their effects on apoptosis induction in human leukemia Jurkat cells and HL-60 cells. Treatment with 20 μM dimethyl sulfides for 24 h decreased the viability of both cells. The cell viability-reducing effect of these sulfides was in the following order: Me2S4 ≈ Me2S3 > Me2S2 ≈ Me2S for Jurkat cells and Me2S4 > Me2S3 > Me2S2 ≈ Me2S for HL-60 cells. Me2S3 and Me2S4 significantly induced DNA fragmentation and caspase-3 activation. The addition of GSH or NAC completely suppressed the sulfide-induced apoptosis. Our results indicate that dimethyl sulfides with a larger number of sulfur atoms more strongly induced apoptosis in both human leukemia cells via ROS production and caspase-3 activation.
- 社団法人 日本農芸化学会の論文
- 2008-11-23
著者
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NAKAMURA Yoshimasa
Graduate School of Natural Science and Technology, Okayama University
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SHIMOISHI Yasuaki
Graduate School of Natural Science and Technology, Okayama University
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MURATA Yoshiyuki
Graduate School of Natural Science and Technology, Okayama University
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Murata Y
Graduate School Of Natural Science And Technology Okayama University
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Miura Yoshie
川崎医科大学 衛生学
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Miura Yoshie
Dep. Of Biofunctional Chemistry Graduate School Of Natural Sci. And Technol. Okayama Univ.
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Shimoishi Yasuaki
Div. Of Bioscience Graduate School Of Natural Sci. And Technol. Okayama Univ.
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Nakamura Yoshimasa
Div. Of Bioscience Graduate School Of Natural Sci. And Technol. Okayama Univ.
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Nakamura Yoshimasa
Graduate School Of Agriculture Kyoto University
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Masamoto Yukimitsu
Graduate School Of Natural Science And Technology Okayama University
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Murata Yoshiyuki
Graduate School Of Natural Science And Technology Okayama University
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ZHANG Gongliang
Graduate School of Natural Science and Technology, Okayama University
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ZHU Beiwei
College of Bio & Food Technology, Dalian Polytechnic University
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Zhu Beiwei
Department Of Biotechnology School Of Biological And Food Engineering Dalian Polytechnic University
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WU Haitao
Graduate School of Natural Science and Technology, Okayama University
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Murata Yoshiyuki
Graduate School Of Natural Science And Technology Okayama Univ.
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Wu Haitao
Graduate School Of Natural Science And Technology Okayama University
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Murata Yoshiyuki
Okayama Univ. Okayama Jpn
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Zhang Gongliang
Graduate School Of Natural Science And Technology Okayama University
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Nakamura Yoshimasa
Graduate School Of Natural Sci. Technol. Okayama Univ.
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Murata Yoshiyuki
Graduate School Of Natural Sci. And Technol. Okayama Univ.
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Shimoishi Yasuaki
Graduate School Of Natural Science And Technology Okayama University
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MURATA Yoshiyuki
Graduate School of National Science and Technology, Okayama University
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