Docosahexaenoic Acid Induces Apoptosis via the Bax-Independent Pathway in HL-60 Cells

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概要

• 論文の詳細を見る

• We attempted to determine whether docosahexaenoic acid (DHA)-induced apoptosis is mediated via the Bax-mediated pathway in human myeloid leukemia HL-60 cells. DHA-induced apoptosis was confirmed by morphological analysis and caspase-3 activation. But, cyclosporin A (CsA), an inhibitor of mitochondrial permeability transition (MPT), did not inhibit DHA-induced Bax translocation to mitochondria or caspase-3 activation. These data suggest that DHA can induce apoptosis via the Bax-independent pathway.

• 社団法人 日本農芸化学会の論文
• 2004-11-23

著者

• MURATA Yoshiyuki

  Graduate School of Natural Science and Technology, Okayama University

• Murata Y

  Graduate School Of Natural Science And Technology Okayama University

• Utsumi Kozo

  Institute Of Medical Science Kurashiki Medical Center

• MIURA Yoshie

  Graduate School of National Science and Technology, Okayama University

• TAKAHATA Kyoya

  Faculty of Agriculture, Okayama University

• TADA Mikiro

  Graduate School of National Science and Technology, Okayama University

• TAKAHARA Keigo

  Graduate School of National Science and Technology, Okayama University

• Takahata K

  Faculty Of Agriculture Okayama University

• Tada M

  Department Of Biological Resources Chemistry Faculty Of Agriculture Okayama University

• Takahata Kyoya

  Faculty Of Agriculture Okayama University

• Murata Yoshiyuki

  Graduate School Of Natural Science And Technology Okayama University

• Tada Mikiro

  Fac. Of Agriculture Okayama Univ.

• Murata Yoshiyuki

  Graduate School Of Natural Science And Technology Okayama Univ.

• Murata Yoshiyuki

  Okayama Univ. Okayama Jpn

• Murata Yoshiyuki

  Graduate School Of Natural Sci. And Technol. Okayama Univ.

• MURATA Yoshiyuki

  Graduate School of National Science and Technology, Okayama University

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