Evaluation of Adenosine 5'-Hexadecylphosphate as an Inhibitor of Acyl-CoA Synthetase Isozyme Functional for Phospholipid Reconstitution in the Yeast Saccharomyces cerevisiae
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概要
- 論文の詳細を見る
Adenosine 5'-hexadecylphosphate (AMPC16) is a mimic of palmitoyl-AMP, a transient intermediate of the acyl-CoA synthetic reaction, and thus could effectively inhibit the activity of palmitoyl-CoA synthetase of Saccharomyces cerevisiae. AMPC16 inhibited the cellular incorporation of [^3H]palmitic acid into phospholipids, in which such an inhibition was most significantly detected in the fraction containing both phosphatidylinositol (PI) and phosphatidylserine (PS). A pulsechase experiment revealed the loss of PI and PS accompanied with accumulation of free fatty acids in AMPC16-treated cells. AMPC16-induced events suggested that Faalp, the major acyl-CoA synthetase isozyme, is functional for phospholipid reconstitution in the exponential growth phase.
- 公益社団法人日本生物工学会の論文
- 2001-11-25
著者
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NAKAYAMA KEIJI
Department of Bio- and Geoscience, Graduate School of Science, Osaka City University
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Nakayama Keiji
Department Of Bio- And Geoscience Graduate School Of Science Osaka City University
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Tanaka Toshio
Department Of Cardiology Matsusaka Central General Hospital
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Tanaka Toshio
Department Of Applied Physics Faculty Of Engineering Tokyo University
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Tanaka Toshio
Department of Applied Chemistry, Faculty of Engineering, Osaka Univeristy
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