Pharmacogenomics of Cardiovascular Pharmacology : Pharmacogenomic Network of Cardiovascular Disease Models
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概要
- 論文の詳細を見る
The most important strategies in pharmacogenomics are gene expression profiling and the network analysis of human disease models. We have previously discovered novel drug target candidates in cardiovascular diseases through investigations of these pharmacogenomics. The significant induction of S100C mRNA and protein expression was detected in the rat pulmonary hypertension and myocardial infarction model. We also found increased taurine in hypoxia, a calcium-associated cytoprotective compound, to suppress the hypoxia-induced S100C gene expression and vascular remodeling. These results suggest that S100C may be one of the potential novel drug targets in hypoxic or ischemic diseases. Delayed cerebral vasospasm after aneurysmal subarachnoid hemorrhage causes cerebral ischemia and infarction. Using a DNA microarray, a prominant upregulation of heme oxygenase-1 (HO-1) and heat shock protein (HSP) 72 mRNAs were observed in the basilar artery of a murine vasospasm model. Antisense HO-1 and HSP 72 oligodeoxynucleotide inhibited HO-1 and HSP 72 induction, respectively, and significantly aggravated cerebral vasospasm. Moreover, we have also developed a unique heart failure model in zebrafish and identified several candidate genes as novel drug targets. These results suggest that pharmacogenomic network analysis has the potential to bridge the gap between in vitro and in vivo studies and could define strategies for identifying novel drug targets in various cardiovascular diseases.
- 社団法人 日本薬理学会の論文
- 2008-05-20
著者
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Tanaka Toshio
Department Of Respiratory Medicine Allergy And Rheumatic Disease Osaka University Graduate School Of
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WANG Zhipeng
Department of Pharmacology, School of Pharmacy, Fourth Military Medical University
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SAKAMOTO Chikara
Department of Obstetrics and Gynecology, Faculty of Medicthe, Kyushu Univercity
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Wang Zhipeng
Department Of Molecular And Cellular Pharmacology Pharmacogenomics And Pharmacoinformatics Mie Unive
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Wang Zhipeng
Department Of Frontier Materials Nagoya Institute Of Technology
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OKA Takehiko
Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie Uni
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SHIMADA Yasuhito
Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie Uni
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UMEMOTO Noriko
Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie Uni
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KUROYANAGI Junya
Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie Uni
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ZANG Liqing
Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie Uni
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NISHIMURA Yuhei
Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie Uni
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Tanaka Toshio
Department Of Cardiology Matsusaka Central General Hospital
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Zang Liqing
Department Of Molecular And Cellular Pharmacology Pharmacogenomics And Pharmacoinformatics Mie Unive
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Oka Takehiko
Department Of Molecular And Cellular Pharmacology Pharmacogenomics And Pharmacoinformatics Mie Unive
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Umemoto Noriko
Department Of Molecular And Cellular Pharmacology Pharmacogenomics And Pharmacoinformatics Mie Unive
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Nishimura Yuhei
Department Of Molecular And Cellular Pharmacology Pharmacogenomics And Pharmacoinformatics Mie Unive
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Sakamoto Chikara
Department Of Bio-science Nagahama Institute Of Bio-science And Technology
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Sakamoto Chikara
Department Of Molecular And Cellular Pharmacology Pharmacogenomics And Pharmacoinformatics Mie Unive
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Shimada Yasuhito
Department Of Molecular And Cellular Pharmacology Pharmacogenomics And Pharmacoinformatics Mie Unive
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Kuroyanagi Junya
Department Of Molecular And Cellular Pharmacology Pharmacogenomics And Pharmacoinformatics Mie Unive
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Tanaka Toshio
Department Of Biomedical Laboratory Sciences Graduate School Of Health Sciences Tokyo Medical And De
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Tanaka Toshio
Department Of Molecular And Cellular Pharmacology Pharmacogenomics And Pharmacoinformatics Mie Unive
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Tanaka Toshio
Department Of Applied Physics Faculty Of Engineering Tokyo University
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Tanaka Toshio
Department of Applied Chemistry, Faculty of Engineering, Osaka Univeristy
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