A Possible Mechanism of NK Cell-lineage Granular Lymphocyte Proliferative Disorder (NK-GLPD) in a Patient with Chronic Active Epstein-Barr Virus Infection (CAEBV) and Severe Hypersensitivity to Mosquito Bites (SHMB)
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概要
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We report the case of a young female patient with chronic active Epstein-Barr virus infection (CAEBV) and severe hypersensitivity to mosquito bites (SHMB). She showed a marked increase of NK cell population in peripheral blood. The NK cell population was suggested to be infected with EBV, and to be oligoclonal by Southern blotting using an EBV genome terminal-repeat probe. The NK cells aberrantly expressed CD25, a high affinity receptor for IL-2, and showed an augmented in vitro proliferative response to IL-2. Moreover, they also showed enhanced expression of both Fas-ligand and Bcl-2, and resistance to in vitro Fasinduced apoptotic cell death (Fas-ACD). Taken together, these observations suggested that both the augmentation of proliferative response to IL-2 and the decrease in Fas-ACD may cause NK cell lineage granular lymphocyte proliferative disorder (NK-GLPD) in patients with CAEBV and SHMB.(Internal Medicine 41: 651-656, 2002)
- 社団法人 日本内科学会の論文
- 2002-08-01
著者
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Tanaka Toshio
Department Of Respiratory Medicine Allergy And Rheumatic Disease Osaka University Graduate School Of
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Asada Hideo
The Department Of Dermatology Osaka University Medical School
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Kawase Ichiro
Department Of Internal Medicine Osaka University
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YAMAGUCHI Norihiko
Department of Internal Medicine Osaka University
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ISHII Taeko
Department of Internal Medicine Osaka University
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OHSHIMA Shiro
The Department of Molecular Medicine, Osaka University Medical School
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ISHII Masaru
The Department of Molecular Medicine, Osaka University Medical School
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TATEKAWA Toyoshi
Division of Internal Medicine, Kinki-Central Hospital
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YAMAGUCHI Norihiko
The Department of Molecular Medicine, Osaka University Medical School
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KOBAYASHI Hideyuki
The Department of Molecular Medicine, Osaka University Medical School
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ISHII Taeko
The Department of Molecular Medicine, Osaka University Medical School
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MIMA Toru
The Department of Molecular Medicine, Osaka University Medical School
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KAWASE Ichiro
The Department of Molecular Medicine, Osaka University Medical School
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SAEKI Yukihiko
The Department of Molecular Medicine, Osaka University Medical School
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Tanaka Toshio
Department Of Respiratory Medicine Allergy And Rheumatic Diseases Osaka University Medical School
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Mima Toru
Division Of Rheumatology National Hospital Organization Osaka-minami Medical Center
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Ohshima Shiro
Division Of Clinical Investigation National Hospital Organization Osaka-minami Medical Center
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Saeki Yukihiko
Department Of Clinical Investigation National Hospital Organization Osaka-minami Medical Center
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Ishii Masaru
Department Of Rheumatology Nho Osaka-minami Medical Center
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SAEKI Yukihiro
Department of Clinical Research
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Kobayashi Hideyuki
The Department Of Internal Medicine Koseiren Sanjo General Hospital
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Kobayashi Hideyuki
The Department Of Molecular Medicine Osaka University Medical School
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Suzuki Yukio
San-ei-gen F.f.i. Inc.
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SAEKI Yukihiko
the Department of Molecular Medicine and Obstetrics Osaka University Medical School
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ISHII Taeko
The Department of Internal Medicine, Graduate School of Medicine, Osaka University
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YAMAGUCHI Norihiko
The Department of Internal Medicine, Graduate School of Medicine, Osaka University
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SAEKI Yukihiko
The Department of Internal Medicine, Graduate School of Medicine, Osaka University
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OHSHIMA Shiro
The Department of Internal Medicine, Graduate School of Medicine, Osaka University
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ISHII Masaru
The Department of Internal Medicine, Graduate School of Medicine, Osaka University
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KAWASE Ichiro
The Department of Internal Medicine, Graduate School of Medicine, Osaka University
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