Possibility of Preventive Treatment for EBV-associated NK Cell-lineage Proliferative Disorders

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概要

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• Objective Chronic active EBV infections (CAEBV) are often causative of malignant lymphoproliferative disorders, such as natural killer (NK) cell-lineage granular lymphocyte proliferative disorders (NK-GLPD), which are refractory to several conventional chemotherapies and usually show a poor prognosis. To explore the possibility of preventive treatment for Epstein-Barr virus (EBV)-infected NK-GLPD, we examined the effect of antiviral drugs on EBV-infected pre-malignant NK cells. Methods EBV-infected pre-malignant NK cells (P-NK cells) were isolated from the periphery of a patient suffering from severe hypersensitivity to mosquito bites (SHMB). Abnormal oligoclonal expansion of EBV-infected CD56(+)/CD3(-) NK cells was observed in her periphery. Effects of several antiviral drugs were examined both on the proliferation and on EBV-replication of P-NK cells. Results Vidarabine and foscarnet, but not acyclovir nor gancyclovir, significantly suppressed both the proliferation and EBV-DNA replication of P-NK cells in a dose-dependent manner, whereas these drugs did not suppress the proliferation of YT, which is an EBV-infected malignant NK cell line. The combination of vidarabine and foscarnet had an additive effect and almost completely suppressed the proliferation of P-NK cells. Conclusion The present results indicate that vidarabine and/or foscarnet may be effective for preventive treatment of EBV-associated NK-GLPD.(Internal Medicine 42: 250-254, 2003)

• 社団法人　日本内科学会の論文

著者

• OHSHIMA Shiro

  The Department of Molecular Medicine, Osaka University Medical School

• ISHII Masaru

  The Department of Molecular Medicine, Osaka University Medical School

• KAWASE Ichiro

  The Department of Molecular Medicine, Osaka University Medical School

• SAEKI Yukihiko

  the Department of Molecular Medicine and Obstetrics Osaka University Medical School

• ISHII Taeko

  The Department of Internal Medicine, Graduate School of Medicine, Osaka University

• YAMAGUCHI Norihiko

  The Department of Internal Medicine, Graduate School of Medicine, Osaka University

• MORI Kiyoshi

  The Department of Internal Medicine, Juntendo University School of Medicine

• KlMURA Hiroshi

  The Department of Pediatrics, Nagoya University School of Medicine

• MORISHIMA Tsuneo

  The Department of Pediatrics, Nagoya University School of Medicine

• SAEKI Yukihiko

  The Department of Internal Medicine, Graduate School of Medicine, Osaka University

• OHSHIMA Shiro

  The Department of Internal Medicine, Graduate School of Medicine, Osaka University

• ISHII Masaru

  The Department of Internal Medicine, Graduate School of Medicine, Osaka University

• KAWASE Ichiro

  The Department of Internal Medicine, Graduate School of Medicine, Osaka University

関連論文

• A Possible Mechanism of NK Cell-lineage Granular Lymphocyte Proliferative Disorder (NK-GLPD) in a Patient with Chronic Active Epstein-Barr Virus Infection (CAEBV) and Severe Hypersensitivity to Mosquito Bites (SHMB)
• A Novel Interpretation of Closing Volume Based on Single-Breath Nitrogen Washout Curve Simulation
• A Possible Mechanism of NK Cell-lineage Granular Lymphocyte Proliferative Disorder (NK-GLPD) in a Patient with Chronic Active Epstein-Barr Virus Infection (CAEBV) and Severe Hypersensitivity to Mosquito Bites (SHMB)
• Possibility of Preventive Treatment for EBV-associated NK Cell-lineage Proliferative Disorders

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