Accelerated Evolution in the Protein-coding Region of Galectin cDNAs, Congerin I and Congerin II, from Skin Mucus of Conger Eel (Conger myriaster)
スポンサーリンク
概要
- 論文の詳細を見る
Two cDNAs encoding galectins named congerins I and II from the skin mucus of conger eel (Conger myriaster) were isolated and sequenced. Comparison of the nucleotide sequences of congerins I and II showed that the sequence similarities of the 5'and 3' untranslated regions (86 and 88%, respectively) were much higher than those of the protein-coding region (73%). The numbers of nucleotide substitutions per site (K_N) for the untranslated regions are smaller than the numbers of nucleotide substitutions per synonymous site (K_S) for the protein coding region. Furthermore, nonsynonymous nucleotide substitutions have accelerated more frequently than synonymous nucleotide substitutions in the protein coding region (K_A/K_S=2.57). These results suggest that accelerated substitutions have occurred in the protein-coding regions of galectin genes to generate diverse galectins with different molecular properties. Northern blot analysis showed that both congerins were expressed not only in the skin tissues but also in the stomach of conger eel.
- 社団法人日本農芸化学会の論文
- 1999-07-23
著者
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小川 智久
Graduate School Of Life Sciences Tohoku University
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Ogawa T
Animal Resource Science/veterinary Medical Science University Of Tokyo
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KAMIYA Hisao
Department of Marine Biochemistry, School of Marine Sciences, Kitasato University
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MURAMOTO Koji
Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University
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村本 光二
Lab. Of Functional Biomolecules Graduate School Of Life Sciences Tohoku Univ.
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OGAWA Tomohisa
Department of Biomolecular Science, Graduate School of Life Sciences, Tohoku University
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Kamiya H
Department Of Marine Biochemistry School Of Marine Sciences Kitasato University
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Kamiya Hisao
Department Of Marine Biochemistry School Of Fisheries Sciences Kitasato University
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Muramoto Koji
Laboratory Of Applied Phytochemistry Tohoku University Graduate School Of Agricultural Science
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Muramoto Koji
Department Biomolecular Science Tohoku University
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ISHII Chihiro
Department of Molecular Life Science, Graduate School of Life Sciences, Tohoku University
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KAGAWA Daiji
Department of Biological Resource Sciences, Graduate School of Agricultural Science, Tohoku Universi
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Ishii Chihiro
Department Of Molecular Life Science Graduate School Of Life Sciences Tohoku University
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Kamiya H
Department Of Marine Biochemistry School Of Fisheries Sciences Kitasato University
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Ogawa T
Laboratory Of Cellular Biochemistry Veterinary Medical Science/animal Resource Science The Universit
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Kagawa Daiji
Department Of Biological Resource Sciences Graduate School Of Agricultural Science Tohoku University
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