Effects of Axial Dispersion and Mass Transfer Resistance on Conversion in a Hollow Fiber Enzyme Reactor

概要

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A hollow fiber module, an artificial kidney consisting of 8,000 fibers of 0.025 cm in diameter and 16 cm in length, was used as a reactor for hydrolysis of sucrose. In the tube side of the reactor, invertase was encapsulated and reactant liquid with dissolved sucrose was fed continuously to the shell side. The axial dispersion coefficient of the reactant fluid in the shell side was measured by step change of blue-dextran solution to correct the influence of liquid mixing on mass transfer rate, and the coefficients were found to be neary constant irrespective of fluid velocities. The value of the Bodenstein number, PeB, was 5.3. Also the mass transfer resistance, 1/K_<os> (min/cm) of the sucrose was measured and was correlated by the following equation as a function of interstitial liquid velocity, V_s (cm/min). 1/K_<os>=121.5+227.7V_s^<-0.6> Theoretical analysis based on the axial dispersion model was carried out to predict the degree of conversion in the reactor. Good agreement was obtained between the predicted values and the experimental data.
公益社団法人日本生物工学会の論文
1980-10-25