<Originals>Morphological study on alveolar damage due to NO_2 inhalation in aging rats
スポンサーリンク
概要
- 論文の詳細を見る
The purpose of this experiment was to clarify morphologically the differences in alveolar damage due to NO_2 inhalation between young and old rats. Three- and 85-week-old rats were used in the experiment. The animals were exposed to 15 ppm NO_2 continuously for 18 days. The lung tissue was examined chronologically by both light and transmission electron microscope. In old rats, alveolar edema was observed clearly 4 days after initial exposure. At seven days after exposure, the alveolar edema had disappeared, but marked interstitial edema was observed in the vas circumference. In young rats, neither alveolar edema nor interstitial edema were observed during the exposure period. Observation under a transmission electron microscope of old rats 4 days after exposure, showed desquamation from the basal membrane in the alveolar 1 type epithelium, and swelling and vacuolation in the capillary endothelium. In old rats 7 days after exposure, the capillary endothelium showed a decrease in the pinocytotic vesicles and disruption of the tight junction. Desquamation from the basal membrane was not observed in the alveolar 1 type epithelium. In old rats 18 days after exposure, the capillary endothelium showed a decrease in pinocytotic vesicles and bleb formation. The endothelial and epithelial damage was slighter in young rats than in old rats during the exposure period. Our observation has clarified that endothelial damage continued during exposure, and that endothelial cells are more sensitive to NO_2 damage in aged rats, resulting in edema and interstitial fibrosis.
- 近畿大学の論文
著者
-
Shirotani Hitoshi
Cardiac Surgical Unit Kinki University Hospital
-
Hara Satoshi
First Department Of Surgery Kinki University School Of Medicine
-
Satou T
Second Department Of Pathology Kinki University School Of Medicine
-
HASHIMOTO Shigeo
Second Department of Pathology, Kinki University School of Medicine
-
Hiruma Shingo
Second Department Of Pathology Kinki University School Of Medicine
-
Satou Takao
Second Department Of Pathology Kinki University School Of Medicine
-
SHIMOTO Takashi
Second Department of Surgery, Kinki University School of Medicine
-
Hashimoto Shigeo
Second Department Of Pathology Kinki University School Of Medicine
-
Shimoto T
Second Department Of Pathology Kinki University School Of Medicine
-
MAEKURA Shunji
Second Department of Pathology, Kinki University School of Medicine
-
Hashimoto S
Niigata Univ. Niigata Jpn
-
Hiruma Shingo
The Second Department Of Pathology Kinki University School Of Medicine
-
Maekura S
Second Department Of Pathology Kinki University School Of Medicine
-
Maekura Shunji
Second Department Of Pathology Kinki University School Of Medicine
-
Hiruma Shingo
Kansai Women Coll. Osaka Jpn
-
Shirotani Hitoshi
Heart Institute Amagasaki Hospital
-
Hashimoto Shigeo
The Second Department Of Pathology Kinki University School Of Medicine
-
Hashimoto Shigeo
Second Department Of Pathology Kinki University Schcol Of Medicine
-
Shirotani Hitoshi
Department Of Cardiovascular Surgery Hyogo Kenritsu Amagasaki Hospital
-
Shirotani Hitoshi
Hyogo Kenritsu Amagasaki Hospital Division Of Cardiovascular Surgery
-
SHIMOTO Takashi
Second Department of Pathology, Kinki University School of Medicine
関連論文
- Leiomyomatosis in pelvic lymph nodes : case report and differential diagnoses
- Retrospective analysis of terminal hepatocellular carcinoma based on laboratory findings
- A intravascular papillary endothelial hyperplasia of the lip with expressing vascular endothelial growth factor
- A case of malignant transformation in thoracic vertebral hemangioma following repetitive irradiation and extraction
- EXPERIENCE WITH VALVED CONDUITS FOR REPAIR OF COMPLICATED CARDIAC ANOMALIES : Congenital heart disease : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- Natural History and Postoperative Evaluation of Complete Transposition of the Great Arteries : Natural History and Postoperative Course of Congenital Heart Diseases
- Occurrence of Long-spacing Collagen in the Intramuscular Nerves of Biopsied Muscle Tissues
- Creutzfeldt-Jakob disease preceded by anesthetic blocks and surgical decompression of the facial nerve
- Primary cardiac lymphoma as a complication of Sjogren's syndrome
- The significance of bivatiate cytokeratin and DNA flow cytometry in paraffin-embedded specimens of non-small cell lung cancer
- Liver and lung metastases from colorectal carcinoma : analysis of DNA ploidy and proliferative activity by flow cytometry
- Timing of Surgical Treatment for Active Native Valve Endocarditis
- A coin lesion due to pulmonary infarction : a case report
- An experience of sleeve lobectomy for metastatic lung tumor from rectal cancer
- FACTORS AFFECTING BIVENTRICULAR FUNCTION FOLLOWING SURGICAL REPAIR OF TETRALOGY OF FALLOT
- Postoperative Long-Term Results in Total Correction of Tetralogy of Fallot : with Special Reference to Method and Degree of Relief of Right Ventricular Outflow Tract Obstruction
- RECONSTRUCTION OF PULMONARY ARTERY WITH SUBSTITUTE VALVE : With Special Reference to Size of Conduit and Valve
- ANGIOCARDIOGRAPHIC EVALUATION OF VENTRICULAR SEPTAL DEFECT : Pre- and Post-operative Cardiac Volume Characteristics
- SURGICAL CORRECTION OF VALVE DISEASE IN THE CHILDREN : Congential Heart Disease : 46th Annual Scientific Meeting, Japanese Circulation Society
- SURGICAL RESULTS AND FACTORS AFFECTING OPERATIVE MORTALITY IN TOTAL ANOMALOUS PULMONARY VENOUS DRAINAGE
- ANATOMICALLY CORRECTED MALPOSITION OF THE GREAT ARTERIES : Case Reports and a Review
- Successful Surgical Repair of Corrected Transposition of the Great Arteries (S, L, L, ) with Ventricular Septal Defect and Regurgitation of the Left Atrioventricular Valve. A Case Report
- CARDIAC VOLUME BEFORE AND AFTER SURGERY IN TOTAL ANOMALOUS PULMONARY VENOUS RETURN : Cardiac Surgery: Valvular and Congenital Heart Disease : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Total Correction of Congenital Heart Disease Using Deep Hypothermia and Complicated Cardiac Anomalies
- 61) Successful Total Repair of Taussig-Bing Malformation. : 第41回日本循環器学会近畿地方会
- 70) Case report : One stage correction of complicated cardiac anomalies with asplenia syndrome : endocardial cushion defect, total anomalous pulmonany venous drainage, d-loop double-Outlet right ventricle with d-transposition and pulmonary stenosis : 第39回
- Experimental investigation of the reactivity of lectin binding to the normal vascular endothelium
- CAF versus CAF plus Medroxyprogesterone Acetate for Treatment of Liver Metastases of Breast Cancer
- Endocrine therapy sensitivity test for breast cancer using collagen gel droplet embedded culture
- Acute Adrenocortical Insufficiency after the Operation for Closure of VSD : 第34回日本循環器学会近畿地方会
- An autopsy case of cystic brain anomaly and acrania caused by amniotic band syndrome
- Application of the monoclonal rat brain actin to the normal rat brain : immunoflorescence and electron immunogold methed
- Ischemic changes of cytoskeletons in the gerbil brain, especially actin.
- Successful Prcduction of Monoclonal Antilbody to Rat Brain Actin with HVJ M Protein Complex
- Production of anti-type IV collagen antibody and its immunohistochemical application to normal rat kidney
- Histological study of a surgically excised leiomyomatous tumor of the duodenum in a case of von Recklinghausen disease
- Surgical treatment of stage IV carcinoma of the esophagus
- Local excision of the liver with the ultrasonic surgical aspirator for the liver cancer with liver cirrhosis
- Gastric Acid Secretion after Esophagectomy for Carcinoma
- Total Correction for Congenital Heart Disease Associated with Severe Pulmonary Hypertension
- ANALYSIS OF 194 AUTOPSY CASES OF ASPLENIA SYNDROME FOR NINE YEARS (1965-1973) IN JAPAN : IInd Auditorium : PROCEEDINGS OF THE 40TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- ONE-STAGE TOTAL CORRECTION IN INFANCY FOR SEVERE CONGENITAL HEART DISEASES : PROCEEDINGS OF THE 38TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- VENTRICULAR SEPTAL DEFECT IN INFANCY (I) : Proceedings of the 34th Annual Meeting of the Japanese Circulation Society (Part I)
- Morphology of the myoepithelium and the basement membrane in the benign and the malignant condition of the breast : an aid for pathological diagnosis
- A light and electron microscopical study on the dynamics and the resolution of brain edema fluid around the infarction in rat brain
- Brain Metastasis in Malignant Pleural Mesothelioma
- Problems concerning the physiological qualitites of data obtained by "Microdialysis system" in rats
- Effects of various collagens and growth factors on proliferation of meningeal sarcoma cells (MS147)
- Research on lectins as a marker of brain vascular endothelium in various animal species
- An immunohistochemical study of actin filaments in capillary endothelial cells of rat cerebrum
- A Surgical Case of Both Cystic Glioma and Teratoid Tumor with Juxtaposition in the Cerebral Hemisphere of a Young Child
- Immunohistochemical changes of the ischemic heart muscle fibers with anti-actin antibodies
- A Case of Vitamin B_6 Deficiency in a Chronic Alcoholist : Histopathological Study on Biopsied Specimens of Peripheral Nerve and Skeletal Muscle Tissues
- Initial knowledge of pine moth disease of chest wall
- A case of cerebral cysticercosis cellulosae hominis
- Morphological study on alveolar damage due to NO_2 inhalation in aging rats
- A sudden death case of laryngocele accompanied by infarction of the dorso-lateral portion of the medulla oblongata
- Carcinoma of the urinary bladder with a lymphomatous appearance
- Chronological morphometry of reinnervated myelinated nerve fibers in rat muscular branch nerve and intramuscular nerves after severing the sciatic nerve
- Neuronal Changes in Cases of Non-Suppurative Inflammatory Myopathies
- The recovery process of impact spinal cord injury by magnetically evoked EMGs
- Nemaline bodies of skeletal muscle fibers of the neck in a case of pharyngeal cancer
- Cervical intra-epithelial neoplasia (CIN) III of the uterine cervix in a young female associated with AIDS
- Results over a Two-year Period in Complete Transposition of the Great Arteries After Mustard's Procedure : Symposium on Long-term Results Following Surgical Operation of Heart Disease
- Histological Studies on Local Circulatory Disturbances Causing Various Renal Disorders (III) : Interrelationships among Intrarenal Angiospasm, Intrarenal Blood Distribution and Renin Granules
- An Autopsy Case of Creutzfeldt-Jakob Disease with a History of Head Trauma
- Serial observation of basement membrane and laminin during muscle regeneration
- A light and electron microscopical study on transvascular transport of brain edema fluid around cryogenic lesion in rat brain