リボザイムの遺伝子治療への応用 (アンチセンス医薬品の研究開発<特集>)
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概要
著者
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大塚 栄子
北大・薬
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大塚 栄子
北大院・薬
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大塚 栄子
Faculty Of Pharmaceutical Sciences Hokkaido University
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小松 康雄
独)産業技術総合研究所ゲノムファクトリー研究部門
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大塚 栄子
北大
関連論文
- 高等植物FEN-1遺伝子のクローニングおよびその解析
- Studies on tRNA and Related Compounds. XXXVII. Synthesis and Physical Properties of 2'- or 3'-O-(o-Nitrobenzyl) nucleosides : the Use of o-Nitrophenyldiazomethane as a Synthetic Reagent
- Studies on Transfer Ribonucleic Acids and Related Compounds. XVI. Synthesis of Ribooligonucleotides using a Photosensitive o-Nitrobenzyl Protection for the 2'-Hydroxyl Group
- Molecular Dynamics and Free Energy Perturbation Calculations on the Mutation of Tyrosine 45 to Tryptophan in Ribonuclease T_1
- Synthesis and Expression of a Gene for Human Tumor Necrosis Factor
- Synthesis of a Gene Coding for Human Lysozyme
- 2P014紫外線損傷DNA切断抗体の創製
- c-Mycとp21^蛋白質間での直接結合による相互の不活化
- アンチセンス核酸によるリボザイムの切断活性の誘導
- Dewar isomer認識一本鎖抗体の構築
- 大腸菌における抗(6-4)光産物一本鎖抗体の発現と生物学的効果
- 真核生物の複製フォーク複合体の分子集合
- NMRによる抗チミンダイマー抗体のDNA認識機構の解析
- ランダム変異導入による抗体の作製
- 紫外線損傷DNAを認識する抗体の抗原結合部位のNMR解析
- (6-4)光産物を特異的に認識する可溶化型一本鎖抗体の作製
- ヒトPCNAとFEN-1の相互作用の解析
- ヒトPCNAの三量体構造と機能の解析
- ヒトPCNAとp21^の相互作用解析
- ヒト PCNA の構造と機能
- リボザイムの遺伝子治療への応用 (アンチセンス医薬品の研究開発)
- Purification and Characterization of the Product of Chemically Synthesized Human Growth Hormone Gene Expression in Escherichia coli(Biological,Chemical)
- A Large-Scale Synthesis of a Nonadecadeoxyribonucleotide Duplex Having a Sequence Identical to That of Phage φ80 O_R2 by the Phosphoro-p-anisidate Method
- Studies on Transfer Ribonucleic Acids (tRNA) and Related Compounds. XLIX. Solid-Phase Synthesis of Nonadecaribonucleotide Corresponding to the 5'-Half of the Formylmethionine tRNA Deficient in D-Loop and Stem Region
- PARTIAL PURIFICATION AND BIOLOGICAL ACTIVITY OF THE PRODUCT OF CHEMICALLY SYNTHESIZED HUMAN GROWTH HORMONE GENE EXPRESSION IN ESCHERICHIA COLI
- Deoxyribonucleic Acids (DNA) and Related Compounds. XIII. Synthesis of DNA Duplexes Containing a Ribosome Binding Site
- Deoxyribonucleic Acids and Related Compounds. XII. Polymer Support Synthesis of a 46-mer Duplex Containing the Promoter of Galactose Operon of Escherichia coli
- Deoxyribonucleic Acids and Related Compounds. VIII. Solid-Phase Synthesis of Deoxyribooligonucleotides with 3'-Modification by Elongation in the 3'-Direction
- Studies on Transfer Ribonucleic Acids and Related Compounds. XLIV. A Large-Scale Synthesis of the Anticodon Heptanucleotide of Formyl-methionine Transfer Ribonucleic Acid by Using 2'-O-Tetrahydrofuranylnucleosides
- Studies on Transfer Ribonucleic Acids and Related Compounds. XLIII. Synthesis of Oligoribonucleotides by using 5'-Selective Phosphorylation of 2'-O-Tetrahydrofuranyl Nucleosides
- Studies on Transfer Ribonucleic Acids and Related Compounds. XLI. Synthesis of tRNA Fragments containing Modified Nucleosides
- Studies on Deoxynucleic Acids and Related Compounds. VI. Synthesis of Oligodeoxyribonucleotides containing Recognition Sequences for Restriction Endonucleases
- Studies on Deoxynucleic Acids and Related Compounds. IV. Syntheses of an Octanucleotide containing a Recognition Site for Restriction Enzyme Eco RI and of an Arabinosyladenine Analog
- A NEW SYNTHETIC METHOD FOR 5'-TRIPHOSPHORYL-ADENYLYL-(2'-5')-ADENYLYL-(2'-5')-ADENOSINE (2-5A) AND 2-5A CORE USING 3'-O-TETRAHYDROFURANYL-ADENOSINE DERIVATIVES
- Studies on Deoxyribonucleic Acids and Related Compounds. III. Synthesis of Oligodeoxyribonucleotides Complementary to the Anticodon Loop of Escherichia coli tRNA^_f by an Improved Triester Method
- Studies on Deoxyribonucleic Acids and Related Compounds. II. Synthesis of a Decanucleotide containing a Restriction Enzyme (PstI) Recognition Site
- Studies on Transfer Ribonucleic Acids and Related Compounds. XXXIV. Stepwise Diester or Partial Triester Synthesis of Penta-to Octanucleotides Corresponding to Residues 41-46,47-54,61-65 and 66-71 of tRNA^_f of E. coli
- Studies on Transfer Ribonucleic Acids and Related Compounds. XXV. Synthesis of E. coli tRNA^_f 5'-Terminal Tetranucleotide C-G-C-Gp and Its Sequence Analog U-G-C-Gp
- Studies on Transfer Ribonucleic Acids and Related Compounds. XVII. Studies on Protecting Groups of Trisubstituted Phosphates in the Synthesis of Ribooligonucleotides
- 酸素ラジカル及び一酸化窒素(NO)によって生ずるDNA損傷がNIH3T3細胞中で誘発する点変異
- In Vitro Replication Study of Modified Bases in ras Sequences
- RNA鎖の特異的切断法
- 修飾オリゴヌクレオチドの合成と核酸研究への応用
- Blockwise Mechanical Synthesis of Oligonucleotides by the Phosphoramidite Method(Organic,Chemical)
- ピロロ〔2,3-d〕ピリミジンヌクレオシドを含むドデカデオキシリボヌクレオチドの合成とその塩基対形成能 (ヘテロ原子の有機化学) -- (5族元素(窒素,リン,アンチモン))
- Deoxyribonucleic Acids and Related Compounds. XXII. : Synthesis of Genes for Human Nerve Growth Factor and Its Fused Protein
- A NEW SOLID-PHASE SYNTHESIS OF RIBOOLIGONUCLEOTIDES USING THE 3'-PHOSPHORO-p-ANISIDATE PROTECTING GROUP FOR STEPWISE SYNTHESIS IN THE 3'-DIRECTION
- 遺伝子合成と生物学の革命(挑戦者からのメッセージ)
- 奨励賞受賞 紙谷浩之氏の業績
- 核酸合成と分子認識
- 研究費のバブル時代とならないために
- 核酸の合成と機能に関する研究.合成ras遺伝子関連の研究を中心として
- DNA/RNA合成機 (バイオ高性能機器導入・共同利用マニュアル) -- (核酸関連機器)
- リボザイム
- ハンマ-ヘッド型リボザイムの触媒活性に必要なMg2+の結合部位 (1991年の化学-10-)
- RNAを配列特異的に切断するリボザイム
- Synthesis of Wobble Pairing Oligoribonucleotides
- Synthesis and Thermal Stability of Dodecadeoxyribonucleotides Containing Deoxyinosine Pairing with Four Major Bases
- 蛋白質工学とRNA工学
- Synthesis and Properties of Hexanucleotides Containing Deoxyinosine
- Preparation and Characterization of Monoclonal Antibodies Specific for Ribonuclese Inhibitor from Rat Liver
- Overproduction of Cellular and Activated Ha-ras Proteins by Mutating a Synthetic Gene(Biological,Chemical)
- Polynucleotides. XXXIV. Ultraviolet Absorption and Circular Dichroism of ApUpG Analogs containing Modified Adenosine Residues
- Studies of Nucleosides and Nucleotides. LVI. A Versatile Method for the Synthesis of 8-Mercaptoadenosine Nucleotides
- ショウジョウバエの(6-4)photoproductに特異的に結合し切断するヌクレアーゼについて
- Studies on Transfer Ribonucleic Acids and Related Compounds. VII. Synthesis and Properties of Cyclic Oligoadenylic Acids
- リボザイムの構造と分子設計(アンチセンスとリボザイム) (核酸化学の新展開--新しい機能性分子を求めて) -- (核酸の機能)
- Ribozyme--酵素としてのRNA (1987年の化学-5-)
- ras遺伝子産物の活性と構造 (1986年の化学-4-)
- 遺伝子の人工合成とその発現 (1985年の化学)
- Synthesis of Guanosine 5'-Diphosphate.
- Synthesis of Guanosine Diphosphate Mannose
- ピリミジン2量体の変異作用
- Inhibition of c-Ha-ras Gene Expression by Hammerhead Ribozymes Containing a Stable C(UUCG)G Hairpin Loop
- 損傷DNAはどのような点変異を引き起こすか (1992年の化学-6-)
- 2本鎖DNAに対するプロ-ブとしての修飾RNA (1993年の化学-8-)
- Studies on Transfer Ribonucleic Acids and Related Compounds. XXXIX. Chemical Synthesis of Heptadeca- and Hexadecaribonucleotides corresponding to the 3'-Terminus of the tRNA^_f of E. coli
- Studies on Transfer Ribonucleic Acids and Related Compounds. XXXI. Synthesis of the 3', 5'-Bisphosphorylated Hexanucleotide corresponding to Bases (72-77) of tRNA^ from E. coli and Its Base Transition Analog
- Studies on Transfer Ribonucleic Acids and Related Compounds. XXI. : Synthesis and Properties of Guanine Rich Fragments from E. coli tRNA^_f 5'-End
- Studies on Transfer Ribonucleic Acid and Related Compounds. XIII. Synthesis of Trinucleoside Diphosphates, A-U-A and εA-U-A via a Triester Intermediate
- Studies of Nucleosides and Nucleotides. XXII. Phosphorylation of Adenosine using Borate Complex as Protecting Group for 2'-and 3'-Hydroxyl Groups.
- Studies on Coenzyme Analogs. XVII. A New Phosphorylating Agent, 2,6-Lupetidylphos-phorodichloridate, and Some Investigations on the Selective Phosphorylation.
- Studies on Transfer Ribonucleic Acids and Related Compounds. XXXVIII. A Rapid Method for the Synthesis of Ribooligonucleotides by using 3', 5'-Unsubstituted Nucleosides. Synthesis of a Hexanucleotide containing Anticodon Triplet of E. coli tRNA^_f.
- Studies on Transfer Ribonucleic Acids and Related Compounds. X. Synthesis of the Yeast Tyrosine tRNA 5'-Terminal Oligonucleotides
- ハンマ-ヘッド型およびヘアピン型リボザイムの細胞内活性 (1990年の化学-8-)
- RNA用制限酵素としてのリボザイムの設計 (1989年の化学-8-)
- RNA自己切断に必要な塩基配列 (1988年の化学-5-)
- Polynucleotides. XXIX. Synthesis of Deoxyribooligonucleotide Blocks by an Extraction Method
- Studies on Transfer Ribonucleic Acids and Related Compounds. XXVII. Linear and Cyclic Oligonucleotides obtained by Polymerization of Protected Ribonucleoside 3'-Phosphates
- RNA工学シリ-ズ-2-RNAの化学合成とリボザイム活性
- 遺伝情報伝達における損傷DNAの影響
- RNA酵素の設計と合成-2-RNA酵素のin vivo活性
- Selective Removal of Protecting Groups for Phosphomonoesters of Nucleotides by Anodic Oxidation
- Polynucleotides. XXVI. Synthesis of an AUG Analog, 8,2-Anhydro-8-oxy-9-β-D-arabinofuranosyladenine Phosphoryl-(3'-5')-uridylyl-(3'-5')-guanosine
- Polynucleotides. XX. Synthesis of an AUG Analog containing 8,5'-O-Cycloadenosine
- Interactions between Synthetic Nucleotide Analogs and Snake Venom 5'-Nucleotidase
- Studies on Coenzyme Analogs. IX. Synthesis of 6-Alkylamino-9-β-D-ribofuranosylpurine 5'-Monophosphate.
- 抗DNA (6-4) 光産物抗体64M-2のFabのX線結晶学的研究
- イノシンーチミン塩基対を含むオリゴヌクレオチドのX線結晶解析
- Polynucleotides. LIX. Synthesis and Properties of a Deoxyribohexanucleotide corresponding to the EcoRI Recognition Sequence