Synthesis and Thermal Stability of Dodecadeoxyribonucleotides Containing Deoxyinosine Pairing with Four Major Bases
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概要
- 論文の詳細を見る
Eight dodecauncleotides, each containing deoxynosine or deoxyguanosine at a pairing position to one of the four major deoxynuclesides, d(CGCIAATTNGCG)or d(CGCGAATTNGCG)(N=dA, dC, dG and dT), were synthesized by the phosphotriester method in solution. Purification methods which were suitable for milligram quantities of oligonucleotides were established.The thermal stabilities of these duplexes and the circular dichroism spectra suggested that the dodecamers formed duplexes similar to B-deoxyribonucleic acid.
- 社団法人日本薬学会の論文
- 1989-03-25
著者
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大塚 栄子
北大・薬
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岩井 成憲
Faculty of Pharmaceutical Sciences, Hokkaido University
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大塚 栄子
Faculty Of Pharmaceutical Sciences Hokkaido University
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大塚 栄子
北大
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川瀬 靖聡
Faculty of Pharmaceutical Sciences, okkaido University
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岩井 成憲
北海道大学 薬
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川瀬 靖聡
Faculty Of Pharmaceutical Sciences Hokkaido University
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