Synthesis of Wobble Pairing Oligoribonucleotides
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概要
- 論文の詳細を見る
Hexaribonucleotides containing inosine at a pairing position adjacent to the other four major nucleosides (GGINCC, N=A, C, G, U) were synthesized in solution by the phosphotriester method using 2'-O-tetrahydrofuranyl protecting groups. 5'-O-Dimethoxytrityl-2'-O-tetrahydropyranylinosine 3'-O-(metyl-N, N-diisopropyl)phosphor-amidite was used for solid-phase syntheses of decaribonucleotides (CGNGAUCICG, N=A, C, G, U). Thermal stabilities and circular dichroism spectra for these self-complementary duplexes were measured. The stabilizing effects of wobble base pairs in these duplexes were estimated as IC>IA>IU>IG.
- 社団法人日本薬学会の論文
- 1989-09-25
著者
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大塚 栄子
北大・薬
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岩井 成憲
Faculty of Pharmaceutical Sciences, Hokkaido University
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大塚 栄子
Faculty Of Pharmaceutical Sciences Hokkaido University
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大塚 栄子
北大
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小泉 誠
Faculty Of Pharmaceutical Sciences Hokkaido University
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川瀬 靖聡
Faculty of Pharmaceutical Sciences, okkaido University
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岩井 成憲
北海道大学 薬
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川瀬 靖聡
Faculty Of Pharmaceutical Sciences Hokkaido University
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