HPL Assay and Dehydroepiandrosterone Sulfate (DHA-S) Dynamic Test for the Clinical Examination of Fetal and Placental Function

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In order to understand clinical usefulness for monitoring the function of fetoplacental-maternal system, serum hPL, hCG and urinary estriol were measured with systematic serial estimation in comparison with the secretory behavior of these three hormones during pregnancy. Furthermore, DHA-S dynamic test was performed to evaluate the feto-placental function. Following are the summarized data. In normal pregnancy, both estriol and hPL were increased gradually from the beginning of pregnancy to the term in a very close correlation. In threatened abortion which terminated in complete abortion, both estriol and hPL were low, or lowered even though they had been in the normal range at the beginning. In the cases of intrauterine fetal death, both hormones were markedly low. In pregnancy with anencephalus, only estriol was low. On the contrary, hPL was low in the cases of placental dysfunction. In a severe case of Rh sensitization, estriol was abruptly lowered in the course of the 40 th week of gestation. By drip infusion of DHA-S, a remarkable increase of estriol was observed in the second and third trimesters of normal pregnancy, pregnancy with anencephalus and placental dysfunction, but no increase was found in the cases of intrauterine fetal death, hydatidiform mole and normal puerperium. From these results, the authors may conclude that the measurement of estriol contributes to evaluation of the feto-placental unit, the hPL level represents directly the placental function and the DHA-S dynamic test is of much help in evaluating the fetal function.
Japan Society of Clinical Chemistryの論文

HPL Assay and Dehydroepiandrosterone Sulfate (DHA-S) Dynamic Test for the Clinical Examination of Fetal and Placental Function

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