各種絨毛腫瘍(胞状奇胎・破壊性奇胎および絨毛癌)のヌードマウスへの移植実験

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Various types of tissues of trophoblastic tumors such as hydatidiform mole, destructive mole and choriocarcinoma were transplanted to nude mice (BALB/cA-nu/JCL) and the transplanted tissues were studied by histological and histochemical techniques ; autoradiography and immunostaining. No case of a successful transplanting of hydatidiform mole and destructive mole is supposed to have been reported previously, but we recognized such cases in 11/61 (18.3%) and 3/15 (20.0%) respectively. We were unable to succeed in passage, but as for cases of successful transplanting of the 1st generation, there were cases in which a mixture of tissues like choriocarcinoma were confirmed. The present experiment appears to bear a part in the assay of an important problem, i. e. malignant change of trophoblastic neoplasia. Transplantation of choriocarcinoma was easily done as reported by many researchers. We obtained high rates of successful grafting such as 3/3 (100%) in the first generation, 13/15 (86.7 %) in the second generation, 8/15 (53.5%) in the third generation and 3/3 (100%) in thd 4th generation. In spite of the repetition of passage, little change was marked in the forms of tissues and proliferation tended to improve. So it is expected that the above data may he used in various experiments in the future. The data on transplantation of tissues of various types of trophoblastic tumors to nude mice has been reported.
神戸大学の論文

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