妊娠高血圧症妊婦の骨密度

概要

論文の詳細を見る
The authors have already reported that the bone density of normal pregnant women might be kept at the same density as in normal non-pregnant women. However, it might be decreased in women with pregnancy induced hypertension (PIH) by estimating serum calcium levels, serum levels of calcium regulating hormones and calcium secretion into the urine. In order to demonstrate this theory, the degree of bone density in the second metacarpal bone of normal or PIH pregnant women was measured by X-ray using microdensitory method (MD method). In MD method, six indices, such as MCI, d, GSmin, GSmax, ∑GS/D and densitometric pattern, are calculated by computer analysis of the X-ray of the bilateral hands. By the evaluation of the degree of bone atrophy, scores such as 0 better than the regression line of healthy women, which were prepared according to each age, 1 until 1δ to the aggravation, 2 until 2δ, and 3 more than 2δ were totalized and evaluated as normal, initial stage of bone atrophy, 1st degree of bone atrophy, 2nd degree of bone atrophy and 3rd degree of bone atrophy for 0-3 scores, 4-9 scores, 10-12 scores and 13-18 scores, respectively (δ = 1 S.D.). The metacarpal index (MCI) of normal pregnant women in 3rd trimester was more than the mean in all cases, while cases more than 2δ of the mean were noted in 29.4% of mild PIH and 11.8% of severe PIH, and a decreasing tendency of width of bone cortex was considered in PIH women. On the other hand, width of bone marrow (d) increased significantly in mild and severe PIH women. In the index for the density of only bone cortex area (GSmax) in PIH women, cases less than mean -1δ were noted in 29.3% of mild types and in 11.8% of severe types respectively, and a high incidence was noted even though it was insignificant compared with 7.4% of normal pregnant women. In the index of the densities of bone cortex and bone marrow (GSmin), cases less than mean -1δ were noted more frequently in PIH women than normal pregnant women, but in the index of bone density per unit length (∑GS/D) no differences were noted between PIH and normal pregnant women. On the other hand, in densitometric pattern, cases of more than B, the border line of healthy women (A) and early stage of osteoporosis (C), were noted in 7.7% of normal pregnant women, but they were 3 5.3% in mild PIH and 47.1% in severe PIH, and a higher incidence of osteoporosis was noted in PIH women than in normal pregnant women. Moreover, a case of C, which was not recognized in normal pregnant women, was observed in PIH. With regard to the 6 indices mentioned previously, the total score of normal pregnant women was 0-3 in all cases, and not one case judged as osteoporosis was observed. On the other hand, cases with osteoporosis in the early - 2nd stages were noted in 41.2% of mild and severe PIH pregnant women, and the incidence of the cases was significantly high in PIH. In conclusion, the proposal of the authors in a previous report that bone density in PIH women might be decreased according to the kinetics of serum Ca concentrations and Ca regulating hormones was actually confirmed by the estimation of the bone density in X-rays.

妊娠高血圧症妊婦の骨密度

スポンサーリンク

概要

著者

関連論文

スポンサーリンク