Facile synthesis of cyclic dipeptides and detection of racemization.
スポンサーリンク
概要
- 論文の詳細を見る
Several cyclic dipeptides were synthesized by refluxing methanolic solution of dipeptide methyl esters in high yield and purity. Cyclic dipeptides prepared by the Fischer method, the Nitecki method, and the present methanol-reflux method were compared with respect to yield and optical purity. The methanol-reflux method usually gave good results. High-performance liquid chromatography was effectively applied to detect racemization.
- 公益社団法人 日本化学会の論文
著者
-
Izumiya Nobuo
Laboratory Of Biochemistry Faculty Of Engineering Kyushu Sangyo University
-
UEDA Toshihisa
Laboratory of Biomolecular Chemistry, Faculty of Agriculture, Saga University
-
KATO Tetsuo
Laboratory of Biochemistry, Faculty of Science, Kyushu University
-
Saito Morinobu
Laboratory of Biochemistry, Faculty of Science, Kyushu University 33
-
Ueda Toshihisa
Laboratory of Biochemistry, Faculty of Science, Kyushu University 33
-
Kato Tetsuo
Laboratory of Biochemistry, Faculty of Science 33, Kyushu University
関連論文
- Syntheses and Antibacterial Activities of Gramicidin S Analogs Containing L-Ornithine in Place of L-Valine
- Assembly Properties In Vitro of Nuclear Lamin A Mutants in Which the Head Domain Is Deleted Stepwise from the N-terminus
- Efficient synthesis of a new amino acid, (2S,3R,4R)-4-chloro-3-hydroxyproline.
- Studies of bitter peptides from casein hydrolyzate. X. Synthesis and bitter taste of H-Arg-Gly-Pro-Phe-Pro-Ile-Ile-Val-OH corresponding to C-terminal portion of .BETA.-casein.
- Synthesis of unusual aromatic L-amino acids by asymmetric hydrogenation of cyclic dehydrodipeptides.
- Cyclic peptides. XXIII Synthesis of retro-enantio-AM-toxin I.
- Synthesis of a Lactam Analog of AM-Toxin I
- Racemization during the synthesis of histidine-containing peptides.
- Studies of Peptide Antibiotics. XVIII. The Synthesis of Tyrocidine E
- Facile synthesis of (2R,3R)-phenylalanine-2,3-d2 and NMR study on deuterated gramicidin S.
- Resolution of amino acids. XII. Preparation of L-2-amino-5-arylpentanoic acids, constituent amino acids in AM-toxins.
- Stereoselective synthesis of 2,4-diamino acids by asymmetric hydrogenation.
- Studies of Peptide Antibiotics. XXIV. Synthesis of 4,4′-D-Alanine-gramicidin S
- Design and synthesis of amphiphilic basic peptides with antibacterial activity and their interaction with model membrane.
- Ribonuclease T1 Peptides. IV. Synthesis of a Protected Heptapeptide Corresponding to Sequence 17–23
- Syntheses of derivatives of N2-acetyl-N3-glycyl-L-2,3-diaminopropionic acid and their hydrolyses by trypsin.
- Synthetic identification of bitter heptapeptide in tryptic hydrolysate of casein.
- Synthesis of Enantio AM-toxin I
- Resolution of .ALPHA.-formyl-.EPSILON.-acyl-DL-lysines by acylase.
- Studies of Peptide Antibiotics. XX. Synthesis of Tyrocidine B
- Synthesis of four diastereoisomers of histopine.
- Studies of Peptide Antibiotics. XVI. Analogs of Gramicidin S Containing β-Alanine in Place of L-Proline
- Studies on separation of amino acids and related compounds. VIII. Preparative separation of isomeric L-aspartyl-L-phenylalanine methyl esters and related dipeptide esters by ion-exchange chromatography.
- Studies of peptide antibiotics. XXXVI. Synthesis and biological activity of [5,5'-leucine]-gramicidin S2.
- Studies of peptide antibiotics. XXXVIII. Synthesis of S,S'-bi([1-L-hemicystine]-gramicidin S), a dimerized analog of gramicidin S.
- Different acyl specificity between mold and kidney acylases: Correlation of hydrolytic rate to molecular size and electronegative property of acyl group in acyl-L-phenylalanine hydrolysis.
- Configuration of alanine part in natural octopine.
- Facile synthesis of cyclic dipeptides and detection of racemization.
- Syntheses of cyclic decapeptides with four ornithyl residues related to gramicidin S.
- Studies on Separation of Amino Acids and Related Compounds. VII. Separation of L-Aspartyl-(α,β)-L-histidine and of L-Glutamyl-(α,γ)-L-histidine
- Studies of Peptide Antibiotics. XXXI. Syntheses of iso-Gramicidin S and iso-[2,2′-Lysine]-Gramicidin S
- Studies of peptide antibiotics. XLV. Syntheses of gramicidin S-like analogs with macro-ring structures.
- Studies on Separation of Amino Acids and Related Compounds. V. A Racemization Test in Peptide Synthesis by the Use of an Amino Acid Analyzer
- Studies of peptide antibiotics. XXXVII. Synthesis of [1,1',3,3'-L-alanine]-gramicidin S.
- Studies of Peptide Antibiotics. XXVIII. Syntheses of Sesquigramicidin S and Digramicidin S
- Studies of peptide antibiotics. XXXIX. Syntheses of gramicidin S analogs containing L-histidine in place of L-ornithine.
- Studies of Peptide Antibiotics. XXV. Synthesis of an Immediate Precursor of Gramicidin S
- Studies of Peptide Antibiotics. XIX. Syntheses of 1,1′-Leucine-gramicidin S and 1-Leucine-cyclosemigramicidin S
- Peptide synthesis in aqueous solution. I. Application of p-dialkyl-sulfoniophenols as a water-soluble coupling reagent.
- Synthesis of N-Terminal Nonapeptide of Trypsinogen and Its Hydrolysis by Trypsin
- Studies of peptide antibiotics. XXXV. Synthesis of gramicidin S by a fragment solid-phase method.
- Studies of Peptide Antibiotics. XXIII. Syntheses of Linear Decapeptide Analogs with Gramicidin S Sequence
- Stereospecific synthesis of D-isothreonine from L-threonine.
- Studies of Peptide Antibiotics. XXX. Syntheses of Gramicidin S Analogs Containing N-Methylleucine in Place of Leucine
- Studies of peptide antibiotics. XXXIII. Syntheses of gramicidin S analogs containing N-methyl-L-valine in place of L-valine.
- Synthesis of .ALPHA. substance-IB in Saccharomyces cerevisiae.
- Synthesis of cyclo-Diglycyl-L-tyrosyl-diglycyl-L-tyrosyl and Hydrolysis by Chymotrypsin
- Cyclic peptides. IV. Synthesis of diastereomeric dihydro-AM-toxin I and its analogs.
- Studies of peptide antibiotics. XXXIV. Syntheses of tyrocidine A and its analogs containing glycine.