Studies of peptide antibiotics. XXXVI. Synthesis and biological activity of [5,5'-leucine]-gramicidin S2.
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概要
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An analog of gramicidin S, in which 5,5′-proline residues were replaced by leucine, was prepared in order to investigate the effect of the introduction of hydrophobic side groups on the antibacterial activity and on the conformation. Also the solubility problems encountered during the synthesis of this analog are described. No significant effect was observed on the cyclization reaction by the replacement of 5,5′-proline to leucine residues. This analog exhibited comparable biological activity and the similar conformation to the natural gramicidin S. These studies suggested that the imino groups of 5,5′-proline residues have no significant roles on both antibacterial activity and conformation of this antibiotic.
- 公益社団法人 日本化学会の論文
著者
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Izumiya Nobuo
Laboratory Of Biochemistry Faculty Of Engineering Kyushu Sangyo University
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Utsumi Yoko
Laboratory Of Chemistry Fukuoka Dental College
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Izumiya Nobuo
Laboratory of Biochemistry, Fuculty of Science, Kyushu University 33
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Abe Okitoshi
Laboratory of Chemistry, Fukuoka Dental College
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