Studies of Peptide Antibiotics. XX. Synthesis of Tyrocidine B
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概要
- 論文の詳細を見る
A cyclic decapeptide, <I>cyclo</I>-(L-Trp-D-Phe-L-Asn-L-Gln-L-Tyr-L-Val-L-Orn-L-Leu-D-Phe-L-Pro-) (XVIII), having the amino acid sequence of natural tyrocidine B has been synthesized, <I>p</I>-Methoxybenzyloxycarbonyl-Trp-D-Phe-OH was transformed into an acyldipeptide hydroxysuccinimide ester by reagents of hydroxysuccinimide-dicyclohexylcarbodiimide, and the acyldipeptide ester obtained was coupled with a neutral octapeptide. An acyldecapeptide acid thus obtained was subjected to the cyclization reaction. The antibacterial activity of the synthetic product (XVIII) toward Gram positive microorganisms is found to be nearly the same as that of synthetic tyrocidine A, indicating that the L-phenylalanine residue in tyrocidine A can be replaced by L-tryptophan without causing decrease in activity.
- 公益社団法人 日本化学会の論文
著者
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Izumiya Nobuo
Laboratory Of Biochemistry Faculty Of Engineering Kyushu Sangyo University
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Kuromizu Kenji
Laboratory of Biochemistry, Faculty of Science, Kyushu University
関連論文
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