Studies of Peptide Antibiotics. XVIII. The Synthesis of Tyrocidine E
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概要
- 論文の詳細を見る
The synthesis of cyclic decapeptide, <I>cyclo</I>-L-phenylalanyl-D-phenylalanyl-L-asparaginyl-L-glutaminyl-L-phenylalanyl-L-valyl-L-ornithyl-L-leucyl-D-phenylalanyl-L-prolyl, which has the amino acid sequence designated as tyrocidine E by Kurahashi, and the chemical and biological properties of the synthetic product, have been described. The degree of the activity of the synthetic product toward the Gram positive microorganisms is nearly the same as that of tyrocidine A. The results indicate that the L-tyrosine residue in the molecule of tyrocidine A can be replaced by L-phenylalanine without influencing activity.
- 公益社団法人 日本化学会の論文
著者
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Ohno Motonori
Laboratory Of Biochemistry Department Of Chemistry Faculty Of Science Kyushu University
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Waki Michinori
Laboratory Of Biochemistry Department Of Chemistry Faculty Of Science Kyushu University
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Izumiya Nobuo
Laboratory Of Biochemistry Faculty Of Engineering Kyushu Sangyo University
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Matsuura Shuji
Laboratory of Biochemistry, Faculty of Science, Kyushu University
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Makisumi Satoru
Laboratory of Biochemistry, Faculty of Science, Kyushu University
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Mitsuyasu Nobuo
Laboratory of Biochemistry, Faculty of Science, Kyushu University
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Mitsuyasu Nobuo
Laboratory of Biochemistry, Faculty of Science Kyushu University 33,
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Ohno Motonori
Laboratory of Biochemistry, Faculty of Science, Kyushu University
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