Studies on Separation of Amino Acids and Related Compounds. V. A Racemization Test in Peptide Synthesis by the Use of an Amino Acid Analyzer
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概要
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Several tripeptides, H-Gly-DL-Ala-B-OH, in which B residues are DL-alanine, L-valine, L-leucine, L-phenyl-alanine, L-proline, and L-serine have been synthesized and the separation of each glycyltripeptide diastereomers by an amino acid analyzer have been studied. Among six peptides studied, diastereomeric mixtures of H-Gly-DL-Ala-L-Val-OH and H-Gly-DL-Ala-L-Leu-OH were separated completely. A procedure to determine the amounts of LL and DL diastereomer of H-Gly-Ala-Leu-OH by the use of the analyzer was developed, and this procedure was applied to examine the influence of coupling reagents for racemization during coupling of benzyl-oxycarbonyl-glycyl-L-alanine and L-leucine benzyl ester by several reagents.
- 公益社団法人 日本化学会の論文
著者
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Aoyagi Haruhiko
Laboratory Of Biochemistry Faculty Of Science Kyushu University
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Izumiya Nobuo
Laboratory Of Biochemistry Faculty Of Engineering Kyushu Sangyo University
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Muraoka Masako
Laboratory of Biochemistry, Faculty of Science, Kyushu University
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