Synthesis of <I>cyclo</I>-Diglycyl-L-tyrosyl-diglycyl-L-tyrosyl and Hydrolysis by Chymotrypsin
スポンサーリンク
概要
- 論文の詳細を見る
A cyclic hexapeptide, <I>cyclo</I>-(diglycyl-L-tyrosyl)<SUB>2</SUB>, was synthesized by several different routes; the cyclization reactions of a tripeptide active ester, a tripeptide azide, and a hexapeptide azide produced the desired cyclic hexapeptide. The cyclic peptide was hydrolyzed slowly by chymotrypsin to a tripeptide diglycyl-tyrosine, whereas a synthetic linear hexapeptide, diglycyl-L-tyrosyl-diglycyl-L-tyrosine, was hydrolyzed very rapidly to the tripeptide. Since the synthetic <I>cyclo</I>-(diglycyl-L-phenylalanyl)<SUB>2</SUB> was insoluble in a buffer, it was not clear whether an incubation mixture of the substrate and enzyme yielded diglycyl-phenylalanine.
- 公益社団法人 日本化学会の論文
著者
-
Izumiya Nobuo
Laboratory Of Biochemistry Faculty Of Engineering Kyushu Sangyo University
-
Yoshida Norio
Laboratory of Biochemistry, Faculty of Science, Kyushu University
-
Konishi Mitsuhiro
Laboratory of Biochemistry, Faculty of Science, Kyushu University
関連論文
- Syntheses and Antibacterial Activities of Gramicidin S Analogs Containing L-Ornithine in Place of L-Valine
- Efficient synthesis of a new amino acid, (2S,3R,4R)-4-chloro-3-hydroxyproline.
- Studies of bitter peptides from casein hydrolyzate. X. Synthesis and bitter taste of H-Arg-Gly-Pro-Phe-Pro-Ile-Ile-Val-OH corresponding to C-terminal portion of .BETA.-casein.
- Synthesis of unusual aromatic L-amino acids by asymmetric hydrogenation of cyclic dehydrodipeptides.
- Cyclic peptides. XXIII Synthesis of retro-enantio-AM-toxin I.
- Synthesis of a Lactam Analog of AM-Toxin I
- Racemization during the synthesis of histidine-containing peptides.
- Studies of Peptide Antibiotics. XVIII. The Synthesis of Tyrocidine E
- Facile synthesis of (2R,3R)-phenylalanine-2,3-d2 and NMR study on deuterated gramicidin S.
- Resolution of amino acids. XII. Preparation of L-2-amino-5-arylpentanoic acids, constituent amino acids in AM-toxins.
- Studies of Peptide Antibiotics. XXIV. Synthesis of 4,4′-D-Alanine-gramicidin S
- Design and synthesis of amphiphilic basic peptides with antibacterial activity and their interaction with model membrane.
- Ribonuclease T1 Peptides. IV. Synthesis of a Protected Heptapeptide Corresponding to Sequence 17–23
- Syntheses of derivatives of N2-acetyl-N3-glycyl-L-2,3-diaminopropionic acid and their hydrolyses by trypsin.
- Synthetic identification of bitter heptapeptide in tryptic hydrolysate of casein.
- Resolution of .ALPHA.-formyl-.EPSILON.-acyl-DL-lysines by acylase.
- Studies of Peptide Antibiotics. XX. Synthesis of Tyrocidine B
- Synthesis of four diastereoisomers of histopine.
- Studies of Peptide Antibiotics. XVI. Analogs of Gramicidin S Containing β-Alanine in Place of L-Proline
- Studies on separation of amino acids and related compounds. VIII. Preparative separation of isomeric L-aspartyl-L-phenylalanine methyl esters and related dipeptide esters by ion-exchange chromatography.
- Studies of peptide antibiotics. XXXVI. Synthesis and biological activity of [5,5'-leucine]-gramicidin S2.
- Studies of peptide antibiotics. XXXVIII. Synthesis of S,S'-bi([1-L-hemicystine]-gramicidin S), a dimerized analog of gramicidin S.
- Different acyl specificity between mold and kidney acylases: Correlation of hydrolytic rate to molecular size and electronegative property of acyl group in acyl-L-phenylalanine hydrolysis.
- Configuration of alanine part in natural octopine.
- Facile synthesis of cyclic dipeptides and detection of racemization.
- Syntheses of cyclic decapeptides with four ornithyl residues related to gramicidin S.
- Studies on Separation of Amino Acids and Related Compounds. VII. Separation of L-Aspartyl-(α,β)-L-histidine and of L-Glutamyl-(α,γ)-L-histidine
- Studies of Peptide Antibiotics. XXXI. Syntheses of iso-Gramicidin S and iso-[2,2′-Lysine]-Gramicidin S
- Studies of peptide antibiotics. XLV. Syntheses of gramicidin S-like analogs with macro-ring structures.
- Studies on Separation of Amino Acids and Related Compounds. V. A Racemization Test in Peptide Synthesis by the Use of an Amino Acid Analyzer
- Studies of peptide antibiotics. XXXVII. Synthesis of [1,1',3,3'-L-alanine]-gramicidin S.
- Studies of Peptide Antibiotics. XXVIII. Syntheses of Sesquigramicidin S and Digramicidin S
- Studies of peptide antibiotics. XXXIX. Syntheses of gramicidin S analogs containing L-histidine in place of L-ornithine.
- Studies of Peptide Antibiotics. XXV. Synthesis of an Immediate Precursor of Gramicidin S
- Studies of Peptide Antibiotics. XIX. Syntheses of 1,1′-Leucine-gramicidin S and 1-Leucine-cyclosemigramicidin S
- Synthesis of N-Terminal Nonapeptide of Trypsinogen and Its Hydrolysis by Trypsin
- Studies of peptide antibiotics. XXXV. Synthesis of gramicidin S by a fragment solid-phase method.
- Studies of Peptide Antibiotics. XXIII. Syntheses of Linear Decapeptide Analogs with Gramicidin S Sequence
- Stereospecific synthesis of D-isothreonine from L-threonine.
- Studies of Peptide Antibiotics. XXX. Syntheses of Gramicidin S Analogs Containing N-Methylleucine in Place of Leucine
- Studies of peptide antibiotics. XXXIII. Syntheses of gramicidin S analogs containing N-methyl-L-valine in place of L-valine.
- Synthesis of .ALPHA. substance-IB in Saccharomyces cerevisiae.
- Synthesis of cyclo-Diglycyl-L-tyrosyl-diglycyl-L-tyrosyl and Hydrolysis by Chymotrypsin
- Cyclic peptides. IV. Synthesis of diastereomeric dihydro-AM-toxin I and its analogs.
- Studies of peptide antibiotics. XXXIV. Syntheses of tyrocidine A and its analogs containing glycine.