Studies of peptide antibiotics. XXXIV. Syntheses of tyrocidine A and its analogs containing glycine.
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概要
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The synthesis of Tyrocidine A (TA), an antibiotic cyclic decapeptide, was achieved by a revised conventional method. Two analogs of TA, 6-glycine-TA and 7-glycine-TA, were synthesized by a similar method to investigate the contribution of L-phenylalanine<SUP>6</SUP> and D-phenylalanine<SUP>7</SUP> residues in TA to its antibacterial activity. The properties of synthetic TA were identical to natural TA. The antibacterial activities of the two analogs were weaker when compared with TA; the activity of 6-glycine-TA being weaker than 7-glycine-TA. The three cyclic peptides synthesized were subjected to droplet countercurrent chromatography (DCCC) and optical rotatory dispersion (ORD), and the elucidation of the difference in the activities between the two analogs was followed with DCCC and ORD.
- 公益社団法人 日本化学会の論文
著者
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Izumiya Nobuo
Laboratory Of Biochemistry Faculty Of Engineering Kyushu Sangyo University
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Okamoto Kouji
Laboratory of Biochemistry, Faculty of Science, Kyushu University
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Nonaka Kazuhiko
Laboratory of Biochemistry, Faculty of Science 33, Kyushu University
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