Ribonuclease T<SUB>1</SUB> Peptides. IV. Synthesis of a Protected Heptapeptide Corresponding to Sequence 17–23

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概要

• 論文の詳細を見る

• A protected heptapeptide corresponding to sequence 17–23 of ribonuclease T<SUB>1</SUB>, namely benzyloxycarbonyl-L-seryl-L-threonyl-L-alanyl-L-glutaminyl-L-alanyl-L-alanyl-glycine ethyl ester (XIV), was synthesized by two routes. One consisted of the coupling of benzyloxycarbonylseryl-threonine azide with a pentapeptide ester, alanyl-glutaminyl-alanyl-alanyl-glycine ethyl ester. The other consisted of the coupling of benzyloxycarbonyl-seryl-threonyl-alanine azide with a tetrapeptide ester, glutaminyl-alanyl-alanyl-glycine ethyl ester. These four peptide segments were built up by the method of stepwise synthesis. Optical rotations, melting points and chromatographic behavior of XIV prepared by these two routes were found to be identical. Stereochemical homogeneity of the protected heptapeptide ester XIV was established by the digestion of the deblocked heptapeptide ester with leucine aminopeptidase.

• 公益社団法人 日本化学会の論文

著者

• Waki Michinori

  Laboratory Of Biochemistry Department Of Chemistry Faculty Of Science Kyushu University

• Izumiya Nobuo

  Laboratory Of Biochemistry Faculty Of Engineering Kyushu Sangyo University

• KATO Tetsuo

  Laboratory of Biochemistry, Faculty of Science, Kyushu University

• IZUMIYA Nobuo

  Laboratory of Biochemistry, Faculty of Science, Kyushu University

• Makisumi Satoru

  Laboratory of Biochemistry, Faculty of Science, Kyushu University

• Mitsuyasu Nobuo

  Laboratory of Biochemistry, Faculty of Science Kyushu University 33,

• Waki Michinori

  Laboratory of Biochemistry, Faculty of Science, Kyushu University

• Kato Tetsuo

  Laboratory of Biochemistry, Faculty of Science 33, Kyushu University

関連論文

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• Inactivation of Gramicidin S by Acylation of Two Ornithine Residues with Higher Fatty Acids
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