Peptide synthesis in aqueous solution. I. Application of p-dialkyl-sulfoniophenols as a water-soluble coupling reagent.
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概要
- 論文の詳細を見る
(<I>p</I>-Hydroxyphenyl)dimethylsulfonium methyl sulfate(HODMSP·MeSO<SUB>4</SUB><SUP>−</SUP>) was found to be an excellent coupling reagent having a water-soluble property and a high reactivity; it worked as satisfactory as usual active esters in regard to the reactivity, product purity, and racemization. The marked advantage of the HODMSP·MeSO<SUB>4</SUB><SUP>−</SUP> active ester method was the fact that bifunctional residues such as Arg, Lys, Cys, and Tyr could be selectively acylated when the pH of the reaction mixture was controlled. The molluscan neuropeptide FMRFamide(Phe–Met–Arg–Phe–NH<SUB>2</SUB>) was synthesized by this new active ester method for an evaluation of this method to further applications involving peptide syntheses.
- 公益社団法人 日本化学会の論文
著者
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Okai Hideo
Department Of Fermentation Technology Faculty Of Engineering Hiroshima University
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KATO Tetsuo
Laboratory of Biochemistry, Faculty of Science, Kyushu University
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Kouge Katsushige
Sanshin Chemical Industrial Co. Ltd.
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Koizumi Tatsuya
Sanshin Chemical Industrial Co. Ltd.
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