Peptide synthesis in aqueous solution. III. Synthesis and biological activity of cyclohexylamide derivatives of peptides related to a molluscan neuropeptide, FMRFamide (Phe-Met-Arg-Phe-NH2).
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概要
- 論文の詳細を見る
In order to investigate the role of C-terminal Phe<SUP>4</SUP>–NH<SUB>2</SUB> of FMRFamide (Phe–Met–Arg–Phe–NH<SUB>2</SUB>) to the biological activity, 30 kinds of cyclohexylamide derivatives of peptides related to FMRFamide were synthesized and their FMRFamide-like activity was measured. From the results, it was found that the peptide which was placed at C-terminal Phe<SUP>4</SUP>–NH<SUB>2</SUB> by D-Ala–CHA showed only a relaxing activity. Furthermore, it was recognized that Met–Arg–Asp–diCHA inhibited FMRFamide contraction selectively.
- 公益社団法人 日本化学会の論文
著者
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Muneoka Yojiro
Physiological Laboratory Faculty Of Integrated Arts And Sciences Hiroshima University
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Okai Hideo
Department Of Fermentation Technology Faculty Of Engineering Hiroshima University
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Kouge Katsushige
Sanshin Chemical Industrial Co. Ltd.
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Soma Haruko
Department of Fermentation Technology, Faculty of Engineering, Hiroshima University
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Katakai Yukari
Department of Fermentation Technology, Faculty of Engineering, Hiroshima University
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Takemoto Mayumi
Physiological Laboratory, Faculty of Integrated Arts and Sciences, Hiroshima University
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Kondo Miyuki
Department of Fermentation Technology, Faculty of Engineering, Hiroshima University
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