Peptide synthesis in aqueous solution. II. Synthesis and biological activity of a molluscan neuropeptide, FMRFamide (Phe-Met-Arg-Phe-NH2) analogs for N-terminal moiety.
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概要
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In order to elucidate the contribution of the N-terminal moiety (Phe<SUP>1</SUP> or Met<SUP>2</SUP>) of FMRFamide to the activity, 16 kinds of FMRFamide analogs were synthesized and their structure-activity relations are discussed. From the results, it was found that hydrophobic or bulky group in N-terminal contributes to the contractile effect, while the precise length of the side chain of amino acid at 2-position is due to a relaxing effect.
- 公益社団法人 日本化学会の論文
著者
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Muneoka Yojiro
Physiological Laboratory Faculty Of Integrated Arts And Sciences Hiroshima University
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Okai Hideo
Department Of Fermentation Technology Faculty Of Engineering Hiroshima University
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Kouge Katsushige
Sanshin Chemical Industrial Co. Ltd.
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Soma Haruko
Department of Fermentation Technology, Faculty of Engineering, Hiroshima University
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Katakai Yukari
Department of Fermentation Technology, Faculty of Engineering, Hiroshima University
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Takemoto Mayumi
Physiological Laboratory, Faculty of Integrated Arts and Sciences, Hiroshima University
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