Stereoselective synthesis of 2,4-diamino acids by asymmetric hydrogenation.
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概要
- 論文の詳細を見る
A stereoselective synthesis of unusual basic amino acids, ornithine, 2,4-diaminopentanoic acid, and 2,4-diamino-6-methylheptanoic acid, was achieved by the hydrogenation of cyclic α,β-dehydro dipeptides obtained by the condensation of cyclo(–Gly–L(or D)-aminoacyl–) and protected linear or chiral amino aldehydes. The degree of chiral induction greatly depended on the bulkiness of the side chains of α,β-dehydro amino acids. The <I>R</I><SUB>f</SUB> values on paper chromatography of (2<I>S</I>,4<I>S</I> or 2<I>R</I>,4<I>S</I>)-diaminopentanoic acid prepared by the present method were different from the reported values of a compound which had been obtained from metabolic products of <I>Clostridium sticklandii</I> and estimated to be 2,4-diaminopentanoic acid.
- 公益社団法人 日本化学会の論文
著者
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Aoyagi Haruhiko
Laboratory Of Biochemistry Faculty Of Science Kyushu University
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Lee Sannamu
Laboratory Of Biochemistry Faculty Of Science Kyushu University
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Maeda Hiroshi
Laboratory Of Microbiology And Oncology Faculty Of Pharmaceutical Sciences Sojo University
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KATO Tetsuo
Laboratory of Biochemistry, Faculty of Science, Kyushu University
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Park Nam
Laboratory of Biochemistry, Faculty of Science, Kyushu University 33
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Kato Tetsuo
Laboratory of Biochemistry, Faculty of Science 33, Kyushu University
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