Studies of peptide antibiotics. XXXIII. Syntheses of gramicidin S analogs containing N-methyl-L-valine in place of L-valine.
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概要
- 論文の詳細を見る
Two analogs of gramicidin S, [1-<I>N</I>-methyl-L-valine]–gramicidin S and [1,1′-di-<I>N</I>-methyl-L-valine]–gramicidin S, were prepared for the purpose of investigating the contribution of NH group of L-valyl residue in gramicidin S to antibacterial activity. They exhibit weak activity as compared with gramicidin S in the antibacterial test toward microorganisms. The optical rotatory dispersions of these analogs and gramicidin S were measured in ethanol and 8 M urea. It was suggested that both analogs have a different molecular conformation from that of gramicidin S, and that the NH group of valyl residues is necessary for stabilizing the conformation to exhibit biological activity.
- 公益社団法人 日本化学会の論文
著者
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Izumiya Nobuo
Laboratory Of Biochemistry Faculty Of Engineering Kyushu Sangyo University
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Sato Kazuki
Laboratory of Biochemistry, Faculty of Science 33, Kyushu University
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Abe Hayao
Laboratory of Biochemistry, Faculty of Science 33, Kyushu University
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Kato Tetsuo
Laboratory of Biochemistry, Faculty of Science 33, Kyushu University
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Abe Hayao
Laboratory of Biochemistry, Faculty of Science, Kyushu University
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