Studies of Peptide Antibiotics. XXXI. Syntheses of <I>iso</I>-Gramicidin S and <I>iso</I>-[2,2′-Lysine]-Gramicidin S
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概要
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Structural isomers of gramicidin S and [2,2′-lysine]-gramicidin S, namely <I>iso</I>-gramicidin S and <I>iso</I>-[2,2′-lysine]-gramicidin S, were prepared to investigate the influence of the ring size for antibacterial activity and conformation of natural gramicidin S. Each isomer involves two peptide bonds between carboxyl group of valine residue and ω-amino group of ornithine or lysine residue. Two isomers showed no antibacterial activity toward several microorganisms. In the experiment of optical rotatory dispersion, two isomers showed similar shaped curves as gramicidin S in a solvent of ethanol. In 6 M urea, the trough of two isomers was moved significantly, whereas that of gramicidin S remained constant.
- 公益社団法人 日本化学会の論文
著者
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Takiguchi Hideo
Department Of Chemistry Faculty Of Science Fukuoka University
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Izumiya Nobuo
Laboratory Of Biochemistry Faculty Of Engineering Kyushu Sangyo University
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