Studies of peptide antibiotics. XXXVII. Synthesis of [1,1',3,3'-L-alanine]-gramicidin S.
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概要
- 論文の詳細を見る
An analog containing alanyl residues in place of valyl and leucyl residues in gramicidin S, namely [1,1′,3,3′-L-alanine]-gramicidin S, was synthesized to investigate the influence of the bulky side chains of the amino acid residues for antibacterial activity and conformation. The analog has the small aliphatic side chains of alanyl residues on one side of the ring frame in the gramicidin S-structure. In the experiments of optical rotatory dispersion and circular dichroism, this analog gave curves similar in shape to these of gramicidin S, and thus should have a similar conformation to that of gramicidin S. The analog showed, however, no antibacterial activity. Thus the four methyl side chains of alanyl residues in the analog are not sufficient for the substance to exhibit biological activity.
- 公益社団法人 日本化学会の論文
著者
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Ando Setsuko
Department Of Chemistry Faculty Of Science Fukuoka University
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Takiguchi Hideo
Department Of Chemistry Faculty Of Science Fukuoka University
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Nishikawa Hiroshi
Department Of Chemistry Faculty Of Science Fukuoka University
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Izumiya Nobuo
Laboratory Of Biochemistry Faculty Of Engineering Kyushu Sangyo University
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