Studies of Peptide Antibiotics. XXVIII. Syntheses of Sesquigramicidin S and Digramicidin S
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概要
- 論文の詳細を見る
Two macro-ring analogs of gramicidin S, namely <I>cyclo</I>(–L-Val–L-Orn–L-Leu–D-Phe–L-Pro–)<SUB>3</SUB> (sesquigramicidin S) and <I>cyclo</I>(–L-Val–L-Orn–L-Leu–D-Phe–L-Pro–)<SUB>4</SUB> (digramicidin S), were prepared to investigate the influence of the ring size of gramicidin S for antibacterial activity. Several linear analogs such as H–(L-Val–L-Orn–L-Leu–D-Phe–L-Pro)<I><SUB>n</SUB></I>–OH (<I>n</I>=2, 3 and 4) were also prepared as reference compounds. All these macroring and linear analogs showed weaker activity than gramicidin S and synergistic property when each of the analogs is mixed with gramicidin S. Measurements of optical rotatory dispersion were made with these analogs and gramicidin S in solvents of ethanol and 8 M aqueous urea. From these experiments, it was suggested that the mode of antibacterial action of the macro-ring analogs and their conformations are similar to those of the linear analogs.
- 公益社団法人 日本化学会の論文
著者
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Waki Michinori
Laboratory Of Biochemistry Department Of Chemistry Faculty Of Science Kyushu University
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Izumiya Nobuo
Laboratory Of Biochemistry Faculty Of Engineering Kyushu Sangyo University
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KATO Tetsuo
Laboratory of Biochemistry, Faculty of Science, Kyushu University
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Matsuura Shuji
Laboratory of Biochemistry, Faculty of Science, Kyushu University
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