Syntheses and Antibacterial Activities of Gramicidin S Analogs Containing L-Ornithine in Place of L-Valine
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概要
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A gramicidin S analog ([Orn^<1, 1'>]GS・4HCl) containing L-ornithine in place of L-valine at the 1, 1'positions was synthesized by the conventional solution method in order to examine whether this analog had antibacterial activity toward Gram-negative bacteria. In the synthesis of [Orn^<1, 1'>]GS・4HC1, two intermediate analogs ([Orn^<1, 1'>, Orn(For)^<2, 2'>]GS・2HCl and [Orn(Z)^<1, 1'>]GS・2HCl) were obtained. [Orn^<1, 1'>]GS・4HCl and [Orn^<1, 1'>, Orn(For)^<2, 2'>]GS・2HCl showed no activity toward either Gram-negative or Gram-positive bacteria, whereas [Orn(Z)^<1, 1'>]GS・2HCl showed appreciable activity toward only Gram-positive bacteria.
- 社団法人日本農芸化学会の論文
- 1994-05-23
著者
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Izumiya Nobuo
Laboratory Of Biochemistry Faculty Of Engineering Kyushu Sangyo University
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Hashiguchi Atsuko
Laboratory Of Biochemistry Faculty Of Science Kyushu University
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Soejima Y
Kyushu Sangyo Univ. Fukuoka Jpn
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Soejima Yasuhiro
Laboratory of Biochemistry, Faculty of Engineering, Kyushu Sangyo University
関連論文
- Syntheses and Antibacterial Activities of Gramicidin S Analogs Containing L-Ornithine in Place of L-Valine
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