Syntheses of DL-Hydroxylysine and DL-Allohydroxylysine

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概要

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• A diastereomeric mixture of DL-hydroxylysine hydrochlorides was obtained with a good yield through hydrogenation of diethyl (γ-hydroxy-δ-nitro-<I>n</I>-butyl)-acetamidomalonate with palladium catalyst in a solvent of acetic acid, which was followed by hydrolysis of the reduced product. Dicarbobenzoxy lactone was prepared with a yield of 91% from hydroxylysine hydrochloride obtained above. A solution of diastereomeric dicarbobenzoxy lactones in dioxane was treated with sodium hydroxide equivalent to the amount of normal form. The salt obtained after saponification converted into a pure normal dicarbobenzoxy lactone, a pure allo compound being isolated from the unsaponified portion. The two lactones were converted into chromatographically pure normal and allohydroxylysine monohydrobromides by the action of hydrogen bromide in acetic acid.

• 社団法人 日本化学会の論文

著者

• Ohno Motonori

  Laboratory Of Biochemistry Department Of Chemistry Faculty Of Science Kyushu University

• Ohno Motonori

  Laboratory of Biochemistry Faculty of Science Kyushu University

• Izumiya Nobuo

  Laboratory of Biochemistry Faculty of Science Kyushu University

• Izumiya N.

  Laboratory of Biochemistry Faculty of Science Kyushu University

• Fujita Yoshimasa

  Laboratory of Biochemistry Faculty of Science Kyushu University

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