モルモットの発達段階における内耳液電解質濃度

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Under sodium pentobarbital anesthesia (25-35mg/kg, I. P.), cochlear endolymph, scala tympani perilymph and scala vestibuli perilymph were collected from guinea pig fetuses (33 ears) neonates (23 ears) and mature animals (42 ears). Sodium and potassium concentrations were assessed using microflame photometry.1. Na and K levels in the cochlear endolymph were already established by the 49th day of gestation, earlier than in any other mammals except human beings.2. The potassium concentration in the scala tympani perilymph in the fetus was high and almost the same as that in the scala vestibuli perilymph. However, this level decreased after birth, and the potassium level in the scala tympani fell to its characteristic concentration.3. The Na levels in both perilymphs and the K level in the cochlear endolymph in the fetuses and neonates was lower than in mature animals. Thus, the osmotic concentration in the neonate seemed to be lower than in mature animals.
耳鼻咽喉科臨床学会の論文