頭頚部癌患者の難治性術後感染症に対するGamma-Veninの効果--免疫学的パラメ-タ-を指標とした検索

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We gave Gamma-Venin (2.5-10gram) and sensitive antibiotics to patients with head and neck tumor who underwent surgery for the tumor and postoperatively developed severe infection of the wound or other places. Serial changes of immunological parameters were evaluated on the day before administration, 3rd and 7th days thereafter.The following results were obtained.1) Patients with head and neck cancer already have depressed cellular immunity and, therefore, postoperative administration of radiation or chemotherapy further decreases their cellular immunity to critically low levels and exposes them to severe infection. The number of T-lymphocytes sufficient to counteract these infections is between 700 and 400/mm3 and that of B-lymphocytes is less than about 100/mm3.2) Gamma-Venin is very effective for those whose T-lymphocyte number is always above 400/mm3 or recurs above 400/mm3 from below 400/mm3, with a combination of the sensitive antibiotics.3) Gamma-Venin is nearly totally ineffective for those whose T-lymphocyte number is always below 400/mm3 or decreased below 400/mm3 from above that level during the infection.4) The number of B-lymphocytes is remarkably lowered in patients with head and neck cancer, compared to that in normal subjects. During infection the number is much more decreased to extremely low levels but the amount of immunoglobulin in the serum has never been decreased and always stayed at normal levels. The reason for this discrepancy is unknown.5) The increase in the amount of immunoglobulin after the administration of Gamma-Venin is not documented, implying that it has no effect on helper T-lymphocytes to assist B-lymphocytes to produce immunoglobulin.6) The effectiveness of Gamma-Venin is primarily based on humoral immunity of anti-bodies and is not due to cellular immunity.7) Tumor fever is frequently seen in those whose T-lymphocyte number is below 300/mm3 and Gamma-Venin is totally ineffective for these patients.8) The overall cure rate for postoperative infection by Gamma-Venin is 55.6%.

頭頚部癌患者の難治性術後感染症に対するGamma-Veninの効果--免疫学的パラメ-タ-を指標とした検索

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