甲状腺癌再発の指標としてのThyroglobulin値

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The recent development in radioimmunoassay of serum thyroglobulin (HTg) has made it evident that HTg is circulating even in the normal blood. Patients with thyroid tumor have also been found to have elevated levels of HTg, compared to a normal person. When the tumor is surgically removed, HTg decreases to the normal level or becomes undetectable and whenever the tumor recurs, it is again elevated abruptly to much higher levels.Using this phenomenon, HTg has recently come to be used as a postoperative indicator for the recurrence of thyroid tumor, especially carcinoma.Thirty-six patients have been selected in our thyroid tumor clinic in the ENT department and HTg measured every 3 to 6 months after the surgery of thyroid carcinoma.Although only totally or subtotally thyroidectomized patients with 131I ablation have so far been studied in other institutions, hemithyroidectomized patients without 131I ablation have also been examined in our clinic and postoperative HTg in the latter was found to behave in the same manner as that in the former.The following results have been obtained in this investigation.1) HTg gradually decreased to the normal or undetectable level postoperatively in about 3 months on the average, ranging from 1 to 9 months.2) HTg stays within normal ranges or consecutively decreases when there is no recurrence.3) In recurrent cases, HTg begins abruptly to be elevated to much higher levels than before.4) HTg is of no value in differenciating malignant from benign tumors.The role of HTg in the clinical detection of recurrence of malignancy has been said to be ambiguous, but from our investigation it has been concluded that statistically it is a highly valuable indicator for the recurrence of thyroid carcinoma.

甲状腺癌再発の指標としてのThyroglobulin値

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