末梢性顔面神経麻痺に対するステロイド剤とCH3-VB12剤の併用効果について

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Fourty two cases of peripheral facial paralysis were devided into three groups, and were administered Steroid, CH3-VB12, and Steroid plus CH3-VB12 respectively. The effect of these drugs on recovery of facial paralysis was determined using the paralysis score method that had been proposed by Yanagihara (1977), and the integrated EMG method that had been proposed by Yagi (1980).In the case of complete recovery, rated paralysis score and the values of the integrated EMG usually increase linearly. By means of regression analysis, regression line around each value could be determined using the following equation.Y=B·log X+A (Y=score, B=rate of recovery, X=day, A=constant)If we assume Y=100%, X shows the number of days taken for complete recovery and constant B, a rate of recovery.Days taken for complete recovery in Steroid, CH3-VB12 and Steroid plus CH3-VB12 were 67.3, 54.9 and 40.3, and the rate of recovery 80.7, 92.2 and 112.3 respectively.Third group, one that was administered Steroid plus CH3-VB12, took shorter period of time for complete recovery than the other two groups. It is statistically significant. This means that Steroid and CH3-VB12 had a synergistic effect upon recovery of facial paralysis.
耳鼻咽喉科臨床学会の論文