グリセロ-ル経口投与における内耳液電解質濃度の動態

概要

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Under sodium pentobarbital anesthesia (25-35mg/kg), serum, cerebrospinal fluid (CSF) and inner ear fluids from scala tympani perilymph, scala vestibuli perilymph, and scala media endolymph were collected from normal guinea pigs after the oral administration of glycerol (50%, 12ml/kg). The sodium and potassium concentrations were determined by microflame photometry. Increases in sodium concentration were found in CSF, scala tympani perilymph, scala vestibuli perilymph, and scala media endolymph, while no significant change was observed in serum. These sodium increases were considered to be due to the dehydration caused by glycerol, an osmotic agent. Potassium concentration was increased only in scala tympani perilymph. The action of glycerol is slower and stronger after oral administration than intravenous injection.
耳鼻咽喉科臨床学会の論文