グリセロ-ルの外リンパ電解質濃度におよぼす効果 (京都大学医学部耳鼻咽喉科学教室6年間の歩み(1977-1982年)--檜学教授還暦によせて)

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Serum, cerebrospinal fluid (CSF), and inner ear fluids from scala tympani perilymph and scala vestibuli perilymph were collected from normal, anesthetized guinea pigs (Sodium pentobarbital 20-30mg/kg, I. P.) which received both intravenous glycerol injection (1.0ml/kg) and peroral glycerol administration (50W/V%, 12ml/kg). The sodium and potassium concentrations were assessed using microflame photometry.The following results were obtained.1) Serum: There was no significant difference between the two administrations in electrolyte dynamics.2) CSF: With both administrations the sodium concentration was found to be increased rapidly and maintained at high levels until the end of our experiments. The electrolyte dynamics were different with respect to the potassium concentration. It did not change with intravenous administration but with peroral administration it increased slightly.3) Scala Tympani Perilymph: The sodium concentration was increased with both administrations but the type of increasing curve was different. With intravenous injection the curve was transient, while with peroral administration it was a gradual up-slope curve. No change was observed with intravenous administration with respect to the potassium concentration, while with peroral administration an up-slope curve was seen.4) Scala Vestibuli Perilymph: The sodium concentration did not change with intrvenous administration, but it changed with peroral administration. An increase in the potassium concentration was produced with intravenous administration but not with peroral administration.In conclusion, when we use the glycerol test in detecting endolymphatic hydrops, peroral administration of glycerol has been found to be more effective than intravenous glycerol injection. Dehydration occurs most severely 2-3 hours after peroral administration, and the time course resembles the clinical glycerol test.
耳鼻咽喉科臨床学会の論文

グリセロ-ルの外リンパ電解質濃度におよぼす効果 (京都大学医学部耳鼻咽喉科学教室6年間の歩み(1977-1982年)--檜学教授還暦によせて)

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