Experimental Study of Furosemide Migration to Inner Ear Fluid

概要

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Furosemide concentrations in the perilymph, cerebrospinal fluid (CSF) and serum were measured in guinea pigs after intravenous injections of furosemide (40mg/kg, 100mg/kg). The concentration in the serum reached its peak within 5 minutes after injection and then decreased slowly. The concentrations in the perilymph and CSF were about 1/800 of the serum level and kept increased more and more for 60 minutes after injection. Thus, the blood cochlea barrier (blood perilymph barrier) is as impermeable as the blood brain barrier (blood CSF barrier).The furosemide concentration in the perilymph after the injection of 100mg/kg of furosemide was about 6.5 times that after the injection of 40mg/kg. This great increase in the perilymphatic concentration is due to the large increase of free furosemide in the serum.
耳鼻咽喉科臨床学会の論文