利尿剤の内耳液電解質濃度におよぼす効果に関する研究
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Under sodium pentobarbital anesthesia (20-30mg/kg, I. P.), normal guinea pigs were given furosemide and/or glycerol. Serum, cerebrospinal fluid (CSF) and inner ear fluid from the scala tympani perilymph, scala vestibuli perilymph, and scala media endolymph were collected. The sodium and potassium concentrations were determined by microflame photometer (I. L. 443 Instrumentation Lab.).1. Both sodium and potassium concentrations in the serum, CSF, scala tympani perilymph and scala vestibuli perilymph showed characteristic and individual levels.2. Furosemide (15mg/kg, I. V.) caused a marked increase in the sodium concentration in the scala tympani and the vestibuli perilymph, and a slight increase in the CSF; there was no significant change in the serum. The potassium concentration was increased in the scala tympani and vestibuli perilymph; there was no significant change in the CSF or serum. The increase in sodium concentration was considered to be a result of dehydration.3. Glycerol (1.0ml/kg, I. V.) increased the sodium concentration in the CSF and in the scala tympani perilymph; no significant change was observed in the serum, the scala vestibuli perilymph or in the cochlear endolymph. Potassium concentration was increased only in the scala vestibuli perilymph.4. Glycerol (50%, 12ml/kg, P. O.) increased the sodium concentration in the CSF, scala tympani and scala vestibuli perilymph and scala media endolymph; no significant change was observed in the serum. Potassium concentration was increased only in the scala tympani perilymph.The increase of sodium was considered to be the result of dehydration caused by the osmotic effect of glycerol. This action is slower and stronger after oral administration than after intravenous injection.The present study suggests that the inner ear fluids in Meniere's disease (endolymphatic hydrops) might be concentrated by the administration of diuretics, and that in the treatment of Meniere's disease, oral administration is more effective than intravenous injection.
- 耳鼻咽喉科臨床学会の論文
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