キンギョにおける経口投与ウサギIgGの血中移行〔英文〕

概要

論文の詳細を見る
Rabbit antiserum to salmon-gonadotropin (sGtH) was orally administered to goldfish. The plasma concentration of anti-sGtH rabbit IgG in goldfish was estimated by antigen-binding activity of the blood plasma to 125I labeled sGtH, and was expressed as percentage to that of original an-tiserum. After oral administration, the concentration of anti-sGtH rabbit IgG in goldfish plasma markedly increased, and reached a maximum value of 1.27% at 12 hours. This value subsequently decreased gradually to 0.57% at 72 hours. The above results demonstrate that orally administered rabbit IgG is transported from the alimentary canal to blood circulation in goldfish, preserving its antigen-binding activity. In the group of fish to which was administered 1% diluted antiserum, the value of anti-sGtH rabbit IgG concentration was approximately 1% of that of the group ad-ministered 100% antiserum. This fact suggests that protein uptake is not a reaction for excessive protein but occurs even when a small amount of protein was ingested.
日本水産學會の論文