魚類の炎症における血管透過性亢進反応の定量〔魚類の炎症に関する研究-3-〕

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Increased vascular permeability in acute inflammation of fish was measured quantitatively by the blueing method. Carp were inflamed by the injection with 10% formalin into the pectoral fin, and pontaminskyblue was injected intravascularly through the canulae implanted to the dosal aorta. The dye was adsorbed onto blood plasma proteins. And the extent of blueing in inflamed tissue which give an indication of the degree of protein leakage, was estimated by extraction of the dye. Acute exudation of blood plasma was observed only in the first 30 minutes just after formalin treatment, but it did not last longer. The amount of exudation was estimated by the other method, comparing the water contents of control and of inflamed pectoral fins. In formalin inflammation, acute exudation and fairly rapid absorption was observed. In croton oil inflammation, the response appeared more slowly and continued much longer. Diphasic reactions, early and late, were not seen in either case. By the latter method effect of mammalian chemical mediators, histamine, serotonin and kinin were tested. But these were not effective on vascular permeability of fish.
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