魚類の炎症時血管透過性亢進と組織液中の蛋白組成〔魚類の炎症に関する研究-2-〕

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The orbital tissue of carp was inflamed by injection of 1% croton oil in cottonseed oil, and changes in protein composition of the orbital fluid were investigated. Protein contents of this fluid in intact fish were about 41% of the counterpart of the blood plasma. The value was elevated after initiation of inflammation together with the projection of eyeball, caused by the fluid accumulation owing to increased vascular permeability. It reached almost the same levels of the blood plasma after 12 hours, and lowered together with decrease of the fluid, after 48 hours. Some increase in the protein contents was observed also in cottonseed oil injected control, but this was not so much. On starch gel electrophoregram of protein fractions, no differences between the fluid and the blood plasma were observed at any time. From these results, we concluded that in inflammation, barriers of walls of the blood vessels to plasma protein exudation which produce low protein content of the body fluid are broken temporarily, and with increased vascular permeability, the plasma protein leaks out freely to extravascular spaces.
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