免疫不全患者におけるサイトメガロウイルス感染肝の病態

概要

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Histopathological and immunohistochemical findings of the liver of 8 immunocompromised hosts infected with cytomegalovirus (CMV) were studied. CMV infection was diagnosed by detection of typical CMV inclusions or CMV associated antigen.<BR>CMV inclusions were observed in intrahepatic bile duct epithelium, hepatocyte, vascular endothelium in portal area and macropages. Most of the CMV inclusions were present in the nucleus. The cells infected with CMV showed various degenerative changes such as swelling, cytoplasmic vacuolation, nuclear atypia, and anisonucleosis without necrotic changes. The degenerative cells were not associated with inflammatory cellular reaction regardless of basic disease. Only mononuclear infiltration was observed in any of the cases. These histopathological findings were not so severe as to cause liver dysfunction. Concerning the localization of CMV infected cells, they were usually detected hepatocytes in the periportal area or along interlobular septum and in bile duct epithelium with an outer diamerter of 10-35μm.