Studies on the metabolic fate of chenodeoxycholic acid. Metabolic fate in hepatobiliary diseases.:Metabolic fate in hepatobiliary diseases

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In order to clarify the metaboiic fate of chenodeoxycholic acid (CDCA), the changes of bile acid levels in bile and in serum were determined after the oral administration of 11, 12-2H-CDCA, and kinetic parameters were analysed by isotope dilution method. Kinetic parameters of CDCA found in healthy Japanese aduits are fairiy good agreement with the reports of Western reseachers. Furthermore, each parameter obtained from bile was readily identical with that obtained from serum, respectiveiy, suggesting that bile acid kinetics in human can be determined with serum samples in place of biie.<BR>In a case of cholelithiasis, reduction of the pool size and increase of the fractional turnover rate were observed. In patients of intrahepatic cholestasis, a marked reduction of CDCA pool size ahd its synthesis rate were observed. In patients with cirrhosis, the pool size was about three quarters and the synthesis rate was one-half that of the healthy adults.
社団法人日本肝臓学会の論文