PHB YHBワクチン接種成績の比較と抗体価推移および無反応例の免疫学的背景の検討

概要

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In order to prevent the nosocomical infections of hepatitis B virus, 1736 medical staffs including medical and nursing students were inoculated by injection of the two types of HB vaccine, one derived from human blood plasma (PHB vaccine) and the other one from gene recombinant yearst (YHB vaccine), and the rates of acquired anti-HBs were compared.<BR>Furthermore, chronological changes in titers of acquired anti-HBs were studied as well as cellular immune states in non-responder among PHB vaccinee.<BR>In the comparison of rates and titers of acquired anti-HBs in two groups, anti-HBs positive rate of PHB vaccinee remained in 86% after the completion of the vaccinations, and the titer of acquired anti-HBs reached 97CI (RIA). While anti-HBs positive rate af YHB vaccinee reached as higher as 99% and the titer of acquired anti-HBs remained as lower as 39CI (RIA).<BR>In 203 cases of PHB vaccinee, the mean titer of acquired anti-HBs decreased by 55% in average 9 months after the completion of inoculates.<BR>Among 14 non-responders, against 4 dose of vaccination (combined 3 injections of PHB vaccine and one with YHB vaccine), the decrease of cellular immunity was broad in half of them.
社団法人日本肝臓学会の論文